S-(carboxymethyl)-L-cysteine ammonium anhydrous crystal form, and preparation method and applications thereof

A cystine ammonium, anhydrous crystal type technology is applied in the fields of S-(carboxymethyl)-L-cysteine ​​ammonium anhydrous crystal type, preparation and use thereof, which can solve the difficulty of precise control of active ingredient content and is effective. Problems such as low content of ingredients

Active Publication Date: 2020-06-26
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, since the S-(carboxymethyl)-L-cysteine ​​ammonium monohydrate crystal contains a certain amount of moisture, the active ingredient (in S-(carboxymethyl)-L-cysteine ​​ammonium) content It is relatively low, and it is difficult to precisely control the content of active ingredients in the drug when preparing preparations

Method used

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  • S-(carboxymethyl)-L-cysteine ammonium anhydrous crystal form, and preparation method and applications thereof
  • S-(carboxymethyl)-L-cysteine ammonium anhydrous crystal form, and preparation method and applications thereof
  • S-(carboxymethyl)-L-cysteine ammonium anhydrous crystal form, and preparation method and applications thereof

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Effect test

Embodiment 1

[0032] The preparation of embodiment 1 anhydrous S-(carboxymethyl)-L-cysteine ​​ammonium

[0033] Take 1g of S-(carboxymethyl)-L-cysteine ​​ammonium monohydrate and place it in a blast oven at 100°C for 30 minutes, and obtain anhydrous S-(carboxymethyl)-L-cysteine ​​after cooling ammonium acid.

Embodiment 2

[0034] The preparation of embodiment 2 anhydrous S-(carboxymethyl)-L-cysteine ​​ammonium

[0035] Take 1g of S-(carboxymethyl)-L-cysteine ​​ammonium monohydrate, raise the temperature to 120°C in a closed environment, and obtain anhydrous S-(carboxymethyl)-L-cysteine ​​ammonium after cooling .

Embodiment 3

[0036] The preparation of embodiment 3 anhydrous S-(carboxymethyl)-L-cysteine ​​ammonium

[0037] Take 1g of S-(carboxymethyl)-L-cysteine ​​ammonium monohydrate, add it into 15ml of acetone, stir for 30min, and concentrate to dryness at 100°C to obtain anhydrous S-(carboxymethyl)-L-cysteine ammonium cystine.

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Abstract

The invention discloses an S-(carboxymethyl)-L-cysteine ammonium anhydrous crystal form, and a preparation method and applications thereof. The X-powder diffraction pattern of the crystal form is represented by a pattern shown in the description. The preparation method of the crystal form is mild in reaction condition, simple in process and suitable for industrial production. The invention also discloses an application of the crystal form in the preparation of a phlegm eliminating medicine and an application of the crystal form in the preparation of a medicine for preventing and / or treating respiratory system diseases.

Description

[0001] The application date is January 05, 2018, the application number is 201810009959.X, and the title of the invention is "An anhydrous crystal form of S-(carboxymethyl)-L-cysteine ​​ammonium, its preparation method and its use. "A divisional application of the application. Background technique [0002] Carbocisteine ​​(chemical name S-(carboxymethyl)-L-cysteine) is a commonly used respiratory system drug in clinical practice. Studies have shown that long-term regular administration of carbocisteine ​​can improve chronic obstructive pulmonary disease (chronic obstructive pulmonary disease, COPD) and other respiratory disease patients with clinical symptoms, reduce the number of acute attacks (YasudaH, Yamaya M, Sasaki T, et al.Carbocisteine ​​reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease.J AmGeriatr Soc .2006; 54(2):378-80. Jin-Ping Zheng, Nan-Shan Zhong, etc. Effect of carbocisteine ​​on acute exacerbation of chr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C323/58C07C319/20A61K31/198A61P11/10A61P11/00
CPCC07C323/58C07B2200/13C07C319/20A61P11/10A61P11/00
Inventor 王玮黄冰娥王健松裴泽健
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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