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30 results about "S-methylcysteine" patented technology

L-arginine producing strain and its mutation method and usage in producing L-arginine

The present invention relates to the fermentation process of producing L-arginine. By using Corynebacterium crenatum SYA5 screened and preserved by the present lab as parent and through conventional physical and chemical mutation process and multiple structural analog resistance screening, mutant strain SDNN403 is obtained. Through culturing of the mutant strain under optimized condition, L-arginine is produced in the yield level of 30-35 g / L. The strain has high genetic stability, stable yield characteristic, high L-arginine yield level, less produced hetero acids and easy technological amplification, and is suitable four industrial production.
Owner:JIANGNAN UNIV

Strain capable of producing L-arginine and method for producing L-arginine by same

ActiveCN102154160ABacteriaMutant preparationCystine knotD-Arginine
The invention relates to a strain capable of producing L-arginine and a method for producing the L-arginine by the strain and belongs to the technical field of biological engineering. For the strain, Brevibacterium flavum ATCC 14067 is used as a starting strain; nitrosoguanidine is adopted to carry out mutagenesis step by step; mutant strains with histidine and succinic acid auxotrophic strains are screened out so as to cut off a competitive metabolic pathway; and mutant strains (His-, Suc-, D-Argr, SMCr) with resistances of arginine structural analogs and cysteine structural analogs are screened out. The strain is named as Brevibacterium flavum HX1009, is preserved in the China general microbiological culture collection center, has the preservation number of CGMCC No.4464 and has the genetic characters of histidine auxotroph His-, succinic acid auxotroph Suc-, D-arginine resistance D-Argr and S-methyl cysteine resistance SMCr for improving the yield of the L-arginine. Under the optimized condition, the L-arginine is produced by fermentation on a fermentation tank with the volume of 5L to 5M3 and the arginine production level achieves 50 to 70g / L.
Owner:FUJIAN GUTIAN PHARMA

Reagent for liquefying phlegm and protecting nucleic acid

The invention provides a reagent for simultaneously liquefying phlegm and effectively protecting nucleic acid. The reagent contains guanidine, a cysteine derivative and a macromolecule inert particle,wherein guanidine is one or more of guanidine hydrochloride, guanidinium isothiocyanate, guanidine sulfate and guanidine carbonate; the cysteine derivative is one or more of cysteine, acetylcysteine,homocysteine, methylcysteine and cysteine hydrochloride; and the macromolecule inert particle is one or more of a polypropylene particle, a polyethylene particle, a polyvinyl chloride particle and apolystyrene particle. The reagent is a mixed solid of powder and particles and is capable of well permeating into a phlegm sample, and the phlegm sample is adequately mixed, so that phlegm can be adequately liquefied; and meanwhile, the reagent is capable of protecting nucleic acid in the phlegm sample from being degraded at a normal temperature for a long time. The reagent contains simple components and is low in cost, and the production process is simple, and the reagent is easy to use and operate and very suitable for wide clinical use.
Owner:ZHEJIANG JFK BIOLOGICAL TECH

Process for producing l-alpha-methylcysteine derivative

A process for easily producing an L-α-methylcysteine derivative or its salt, which is useful as a drug intermediate, from a cheap easily procurable raw material through an enzymatic D-stereoselective hydrolysis of racemic 5-halomethyl-5-methyl-hydantoin. L-α-methylcysteine derivative or its salt is produced by converting racemic 5-halomethyl-5-methylhydantoin to L-5-halomethyl-5-methylhydantoin through an enzymatic D-stereoselective hydrolysis, reacting the L-5-halomethyl-5-methylhydantoin with a sulfurizing agent into L-5-methyl-5-thiomethylhydantoin and hydrolyzing the L-5-methyl-5-thiomethylhydantoin.
Owner:KANEKA CORP

Injectable parenteral medicinal preparation of temozolomide and preparation method thereof

The invention relates to an injectable parenteral medicinal preparation of temozolomide and a preparation method thereof. The medicinal preparation comprises (1) temozolomide or pharmaceutically acceptable salt thereof, (2) at least one stabilizer, and (3) at least one aqueous diluent, wherein the stabilizer is selected from L-alanine, L-glycine, L-cysteine, L-cysteine hydrochloride anhydride, L-cysteine hydrochloride monohydrate, acetyl cysteine, S-carboxymethyl-L-cysteine, L-ethyl cysteine hydrochloride, L-methyl cysteine hydrochloride, vitamin C or a mixture thereof. The invention further relates to lyophilized power containing the medicinal preparation and products thereof.
Owner:JIANGSU HENGRUI MEDICINE CO LTD

Crystalline pharmaceutical compound and preparation method and usage thereof

The invention relates to an S-(carboxymethyl)-L-cysteine ammonium salt water crystalline pharmaceutical compound (having the following structural formula) and a preparation method and the application of the compound in the preparation of medicines for eliminating phlegm as well as medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases (COPD) and the like. After the compound is adopted, the COPD model rat airway resistance is remarkably reduced, the generation of oxide is reduced, the antioxidant level is increased, and the damage of oxide, inflammatory mediator and the like to the lung can be relieved.
Owner:GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY +1

S-(carboxymethyl)-cysteine pharmaceutical compound and preparation method and usage thereof

The invention relates to an S-(carboxymethyl)-cysteine pharmaceutical compound and a preparation method and the usage of the compound; the structural formula of the compound is shown by (I); and the compound is especially applied to the preparation of medicines for eliminating phlegm as well as medicines for preventing and treating respiratory system diseases such as chronic obstructive pulmonary diseases (COPD) and the like. After the compound is adopted, the COPD model rat airway resistance is remarkably reduced, the generation of oxide is reduced, the antioxidant level is increased, and the damage of oxide, inflammatory mediator and the like to the lung can be relieved.
Owner:GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY +1

Derivatives of erythromycin, clarithromycin, roxithromycin or azithromycin with antibiotic and mucolytic activity

InactiveUS20010031736A1Improved pharmacological profileGood effectBiocideSugar derivativesRoxithromycinAzithromycin
A pharmaceutical with an enhanced pharmaceutical profile comprises a mucolytic and an antibiotic in which the mucolytic is present in an amount of greater than one molar equivalent of the antibiotic. The antibiotic may be selected from Erythromycin, Roxithromycin, Clarithromycin, Azithromycin, Dirithromycin; and pharmaceutically acceptable salts or esters thereof. The mucolytic is a mucolytically active thiol, especially N-acetylcysteine, mercaptoethanesulfonic acid, tiopronin or methylcysteine. The adducts can be isolated via a simple and efficient process.
Owner:RUSSINSKY

Preparation method of S-carboxymethyl-L-cysteine

The invention discloses a preparation method of S-carboxymethyl-L-cysteine, which relates to the field of amino acid production, and mainly comprises the following steps: 1, dissolving L-cysteine hydrochloride monohydrate, cooling the solution to 0-5 DEG C, and regulating the pH value to 9-10 to obtain a solution (a); 2, dissolving chloroacetic acid, and adjusting the pH value to 6-7 to obtain a solution (b); 3, dropwise adding the solution (b) into the solution (a), and carrying out heat preservation to obtain a solution (c); 4, adjusting the pH value of the solution (c) to 8, and heating thesolution to react for 1 hour; 5, cooling the solution (c) to room temperature, adjusting the pH value to 5.5, and filtering the solution; 6, adjusting the pH value of the filtrate to 2.5-3.0, refrigerating the filtrate overnight, carrying out suction filtration, and drying the filtrate to obtain a crude product; 7, dissolving the crude product to obtain a solution (d), and acidifying the solution(d) to an isoelectric point; 8, adding a seed crystal into the solution (d), and adjusting the solution (d) to an isoelectric point; 9, purifying a finish product. By means of the preparation method,S-carboxymethyl-L-cysteine with large particle size, high density and high purity can be obtained, and the preparation method is suitable for being used in multiple fields.
Owner:NINGBO YUANFA BIOENG

Preparation method of chirality 2-methyl cysteine and hydrochloride thereof

The invention discloses a preparation method of chirality 2-methyl cysteine and hydrochloride thereof. The preparation method comprises the following steps: chirality 2-tert-butyl-3-formoxyl thiaxolidine-4-carboxylic ester, a methylation reagent and organic base are subjected to methylation in organic solvent to obtain reaction solution, inorganic base is added in the reaction solution, chirality-invariable 2-tert-butyl-3-formoxyl thiaxolidine-4-methyl-4-carboxylic acid is obtained through one-pot reaction, then the chirality-invariable 2-tert-butyl-3-formoxyl thiaxolidine-4-methyl-4-carboxylic acid is subjected to reflux reaction in hydrochloric acid solution to obtain chirality 2-methyl cysteine hydrochloride, and finally, chirality 2-methyl cysteine is obtained through aftertreatment. Compared with the prior art, the preparation method disclosed by the invention is simple in operating process, the production cost is lower, the reaction yield and the optical purity of products are higher, and excellent industrial application value is realized.
Owner:SYNCOZYMES SHANGHAI

Antibacterial peptide lexapeptide and its preparation method and use

ActiveCN106188253BNo inhibitory activityHigh antibacterial activityAntibacterial agentsAntimycoticsHeterologousLanthiopeptin
The invention discloses an antimicrobial peptide Lexapeptide, and a preparation method and application thereof. The lanthiopeptin antimicrobial peptide Lexapeptide is a new compound obtained through separating after heterologously expressing a bacterial artificial chromosome library derived from a Streptomyces rochei Sal35 bacterial strain in Streptomyces lividans SBT5, is formed by 38 amino acids, and is the lanthiopeptin which is reported for the first time and simultaneously contains a C terminal 2-amidogen alkenyl-3-methyl-aminothiopropionic acid structure and an N terminal methylated modification structure. With the highly structural modification, the Lexapeptide has better stability compared with other lanthiopeptin antimicrobial peptides. The Lexapeptide can be used as an anti-gram-positive bacterium preparation so as to provide a solution for a generally clinical dug-resistance problem.
Owner:SHANGHAI JIAO TONG UNIV

Medicine and functional food for preventing and treating post-traumatic stress syndrome

The invention discloses medicine or functional food for preventing and / or treating post-traumatic stress syndrome. The medicine or functional food consists of S-methyl-L-cysteine(thiomethy L-cysteine)or amino acid salts of thiomethy L-cysteine and additives or / and carriers acceptable in pharmacy or food industry. The S-methyl-L-cysteine can be provided by a plant extract which is used as a raw material and is rich in the S-methyl-L-cysteine. The medicine or functional food can generate a dissipation promoting effect on fear memory related to traumatic stress by reducing oxidative stress levelin a body, reducing free radicals and enhancing synaptic plasticity and other characteristics dependent on NMDA receptors in relevant brain regions, thereby treating behavioral abnormalities caused by post-traumatic stress.
Owner:HUAZHONG UNIV OF SCI & TECH

Novel purpose of S-(carboxymethyl)-L-cysteine

The invention relates to a novel purpose of medicine, in particular to application of S-(carboxymethyl)-L-cysteine and pharmacologically acceptable salts of the S-(carboxymethyl)-L-cysteine to prevention and / or treatment of respiratory system diseases and the like caused by haze. The S-(carboxymethyl)-L-cysteine and the pharmacologically acceptable salts of the S-(carboxymethyl)-L-cysteine are used; and the inflammation damage and oxidation operation of atmosphere PM2.5 on the lungs of mice can be obviously reduced, so that the S-(carboxymethyl)-L-cysteine and the pharmacologically acceptablesalts of the S-(carboxymethyl)-L-cysteine can be applied to preparation of medicine for preventing and treating diseases caused by haze.
Owner:GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY

Method for preparing high-purity chiral 2-smethylcysteine s and hydrochloride of high-purity chiral 2-smethylcysteine s

The invention discloses a method for preparing high-purity chiral 2-smethylcysteine s and hydrochloride of high-purity chiral 2-smethylcysteine s. The method comprises the steps that crude chiral 2-methyl cysteine hydrochloride and a reducing agent are added to an organic solvent, crude chiral 2-methyl cysteine hydrochloride is dissolved at room temperature or under the heating condition, stirring and cooling crystallization are carried out to obtain high-purity chiral 2-methyl cysteine hydrochloride; aftertreatment is carried out on high-purity chiral 2-methyl cysteine hydrochloride to obtain high-purity chiral 2-smethylcysteine s. Compared with the prior art, the adopted method is simple in operation process, low in production cost and high in product purity, and good industrial application value is achieved.
Owner:SYNCOZYMES SHANGHAI

Process for producing optically active alpha -methylcysteine derivative

A process for conveniently and industrially producing an optically active α-methylcysteine derivative, which is useful as an intermediate of medicines and the like, from an inexpensive and readily available material is provided. The present invention relates to a process for producing a racemic or optically active α-methylcysteine derivative including a step of hydrolyzing a racemic or optically active N-carbamyl-α-methylcysteine derivative by treating with decarbamylase, and a process for producing an optically active α-methylcysteine derivative and an optically active N-carbamyl-α-methylcysteine derivative having a configuration opposite to that of the compound including a step of stereoselectively hydrolyzing a racemic N-carbamyl-α-methylcysteine derivative by treating with decarbamylase.
Owner:KANEKA CORP

Application of S-(carboxymethyl)-L-cysteine to preparation of medicines for preventing and treating respiratory system diseases

The invention relates to novel application of medicines, in particular to application of S-(carboxymethyl)-L-cysteine and pharmaceutically acceptable salts thereof to preparation of medicines for preventing and treating respiratory system diseases caused by NF-kappa B signal pathway activation. The application has the advantages that the S-(carboxymethyl)-L-cysteine and the pharmaceutically acceptable salts thereof can remarkably inhibit not only NF-kappa B signal pathway activation and release of inflammatory factors interleukin-6 and interleukin-8 due to H2O2, TNF (rumor necrosis factor)-alpha and cigarette smoke extract but also acute lung injury, release of the interleukin-6 and the interleukin-8 in bronchial asthma mice bronchoalveolar lavage fluid and expression of NF-kappa B in lung tissues remarkably, thereby being applied to prevention and treatment of NF-kappa B-mediated respiratory system diseases such as bronchial asthma, acute lung injury and acute respiratory distress syndrome.
Owner:GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY +1

A kind of preparation method of s-(carboxymethyl)-cysteine

The invention belongs to the technical field of compound preparation and particularly relates to a preparation method of high-purity S-(carboxymethyl)-cysteine. First, L-cysteine hydrochloride is pretreated by a reducing agent before reaction, an aqueous solution of chloroacetic acid is added into the system, and the reaction is continuously carried out in the positive reaction direction with dropping addition of an alkaline solution until the reaction is finished when the pH value of the system is 6.0-12.0, an acid is dropwise added to the vicinity of an isoelectric point of the product, andcrystallization is carried out at low temperature to obtain a crude product; the crude product is dissolved in the alkaline solution at room temperature, an organic acid is dropwise added until a product precipitates when the pH value is about 2.8, the precipitated product is put into a tray, the tray is put on the water surface and is pretreated by heating, moisture in a filter cake is heated until small bubbles are generated in the pretreatment process, and the generated bubbles counter-react with the filter cake, so that substances in the moisture in the filter cake further generate a precipitated product through the vibration effect of the bubbles, and finally the pretreated precipitated product is put into an all-in-one machine to obtain the product.
Owner:北京云鹏鹏程医药科技有限公司

Simple preparation of trifluoromethionine and derivatives thereof

InactiveUS20110015433A1Avoiding the evaporation of ammoniaSimple preparation processOrganic compound preparationAmino-carboxyl compound preparationBirch reductionIodide
Disclosed is a process for the simple preparation of trifluoromethionine, its analogs trifluoromethylcysteine, fluoroalkylhomocysteines, and fluoroalkylcysteines, and derivatives of them. These compounds are drug-candidate compounds or raw materials of drug-candidate compounds. Specifically, trifluoromethionine, trifluoromethylcysteine, a fluoroalkylhomocysteine, or a fluoroalkylcysteine is simply and conveniently prepared directly without passing through homocysteine or cysteine by adding metallic sodium to an optically active or racemic homocystine or cystine in liquid ammonia and further adding a fluoroalkyl iodide thereto under Birch reduction conditions.
Owner:NAGOYA INSTITUTE OF TECHNOLOGY
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