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A kind of s-carboxymethyl-l-cysteine ​​enteric-coated pellet capsule

A technology of cystine injection and cysteine, which is applied in the direction of microcapsules, capsule delivery, drug combination, etc., can solve the problems of unresolved drug side effects, validity period of only 24 months, poor stability, etc., to improve bioavailability High degree, easy to store, improve the effect of stability

Active Publication Date: 2020-09-18
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the existing preparations solves the side effects of drugs on digestive tract irritation
At the same time, the long-term storage stability of the common preparation of S-(carboxymethyl)-L-cysteine ​​is not good, and the validity period is only 24 months

Method used

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  • A kind of s-carboxymethyl-l-cysteine ​​enteric-coated pellet capsule
  • A kind of s-carboxymethyl-l-cysteine ​​enteric-coated pellet capsule
  • A kind of s-carboxymethyl-l-cysteine ​​enteric-coated pellet capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Ball core

[0021] S-carboxymethyl-L-cysteine ​​250mg;

[0022] Carbomer 100mg;

[0023] Hypromellose 80mg.

[0024] Isolation layer

[0025] Talc powder 5mg;

[0026] Hypromellose 5mg;

[0027] Polyethylene glycol 2mg.

[0028] Enteric layer

[0029] Waterborne acrylic enteric coating system 93A 30mg;

[0030] Simethicone 0.3mg;

[0031] PEG8000 3mg.

[0032] Preparation method:

[0033] (1) Pill core containing medicine: take the hypromellose of prescription quantity, add water and dissolve to be binder; Take the S-carboxymethyl-L-cysteine ​​and carbomer of prescription quantity, mix evenly, pass 100-mesh sieve, soft material made of hypromellose solution as binder. Start the extrusion and spheronization equipment, select the aperture of the sieve plate to be 0.8mm, and the rotation speed to be 4000 rpm, and extrude and spheronize to obtain pellets; dry and pass through a 20-mesh sieve to obtain the pellet core.

[0034] (2) Isolation layer: Weigh the pres...

Embodiment 2

[0038] Ball core

[0039] S-carboxymethyl-L-cysteine ​​250mg;

[0040] Carbomer 50mg;

[0041] Hypromellose 30mg.

[0042] Isolation layer

[0043] Talc powder 4mg;

[0044] Hypromellose 2mg;

[0045] Polyethylene glycol 1mg.

[0046] Enteric layer

[0047] Waterborne acrylic enteric coating system 93A 20mg;

[0048] Simethicone 0.2mg;

[0049] Triethyl Citrate 2mg.

[0050] Preparation method:

[0051] (1) Pill core containing medicine: take the hypromellose of prescription quantity, add water and dissolve to be binder; Take the S-carboxymethyl-L-cysteine ​​and carbomer of prescription quantity, mix evenly, pass 100-mesh sieve, soft material made of hypromellose solution as binder. Start the extrusion and spheronization equipment, select the aperture of the sieve plate to be 0.8mm, and the rotation speed to be 4000 rpm, and extrude and spheronize to obtain pellets; dry and pass through a 20-mesh sieve to obtain the pellet core.

[0052] (2) Isolation layer: Weigh th...

Embodiment 3

[0056] Ball core

[0057] S-carboxymethyl-L-cysteine ​​250mg;

[0058] Carbomer 10mg;

[0059] Hypromellose 10mg.

[0060] Isolation layer

[0061] Talc powder 8mg;

[0062] Hypromellose 2mg;

[0063] Polyethylene glycol 2mg.

[0064] Enteric layer

[0065] Water-based acrylic enteric coating system 93A 20mg;

[0066] Simethicone 0.2mg;

[0067] Glyceryl Triacetate 3mg.

[0068] Preparation method:

[0069] (1) Pill core containing medicine: take the hypromellose of prescription quantity, add water and dissolve to be binder; Take the S-carboxymethyl-L-cysteine ​​and carbomer of prescription quantity, mix evenly, pass 100-mesh sieve, soft material made of hypromellose solution as binder. Start the extrusion and spheronization equipment, select the aperture of the sieve plate to be 0.8mm, and the rotation speed to be 4000 rpm, and extrude and spheronize to obtain pellets; dry and pass through a 20-mesh sieve to obtain the pellet core.

[0070] (2) Isolation layer: We...

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PUM

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Abstract

The invention discloses an S-carboxymethyl-L-cysteine enteric pellet. The enteric pellet contains a pellet core, an isolation layer and an enteric layer, wherein the enteric layer is obtained by coating and packaging a water-based acrylic acid enteric-coated material. The invention further discloses an S-carboxymethyl-L-cysteine enteric pellet capsule containing the S-carboxymethyl-L-cysteine enteric pellets. The S-carboxymethyl-L-cysteine enteric pellet capsule disclosed by the invention cannot be dissolved in the stomach, has a little stimulation to the stomach, and is stable in quality in astorage process.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular, the invention relates to a pellet preparation containing S-carboxymethyl-L-cysteine. Background technique [0002] S-(carboxymethyl)-L-cysteine, also known as carboxycisteine, was first developed and used clinically by the French Joullie company in 1961. It is a mucolytic drug that can affect the secretion of bronchial glands. Increase the secretion of low-viscosity salivary mucin, reduce the production of high-viscosity fucoidal mucin, and directly act on the disulfide bond of mucin to crack mucin molecules to reduce the viscosity of sputum and make it easier to spit out ; Can improve mucociliary clearance; reduce airway hyperresponsiveness. After CMC enters the body, it is easy to remove the carboxymethyl group to form cysteine, and the sulfhydryl group contained in it can interact with electrophilic groups such as reactive oxygen species (ROS) to exert a dir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/58A61K31/198A61K47/32A61K47/34A61K47/10A61K47/14A61P11/10A61P11/00A61P11/06
CPCA61K9/5015A61K9/5026A61K9/5031A61K9/5073A61K31/198A61P11/00A61P11/06A61P11/10
Inventor 王玮王健松肖颖裴泽建朱少璇
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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