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A kind of enteric-coated tablet containing s-carboxymethyl-l-cysteine

A technology of cystine injection and cysteine, which is applied in the direction of medical preparations containing active ingredients, pill delivery, and medical preparations with non-active ingredients. Improve bioavailability, easy storage, and reduce irritation

Active Publication Date: 2020-10-16
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the existing preparations solves the side effects of drugs on digestive tract irritation
At the same time, the long-term storage stability of the common preparation of S-(carboxymethyl)-L-cysteine ​​is not good, and the validity period is only 24 months

Method used

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  • A kind of enteric-coated tablet containing s-carboxymethyl-l-cysteine
  • A kind of enteric-coated tablet containing s-carboxymethyl-l-cysteine
  • A kind of enteric-coated tablet containing s-carboxymethyl-l-cysteine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Chip

[0049]

[0050] Isolation layer

[0051] Hypromellose 6mg;

[0052] Enteric layer

[0053] Waterborne acrylic enteric coating system 93A 36.5mg;

[0054] Simethicone 0.37mg;

[0055] PEG8000 2.5 mg.

[0056] Preparation method:

[0057] Weigh the prescribed amount of tablet core materials, mix them evenly, pass through a 100-mesh sieve, make a soft material with water, pass through a 24-mesh sieve, dry the obtained wet granules, and press into tablets. Weigh the prescribed amount of hypromellose, and disperse it with the prescribed amount of purified water to obtain the isolation layer. The enteric-coated layer material is weighed and dispersed with purified water to obtain the enteric-coated layer. Wrap the S-carboxymethyl-L-cysteine ​​tablet with the isolation layer and the enteric-coated layer in turn to obtain the S-carboxymethyl-L-cysteine ​​enteric-coated tablet.

Embodiment 2

[0059] Chip

[0060]

[0061] Isolation layer

[0062] Hypromellose 4mg;

[0063] Enteric layer

[0064] Waterborne acrylic enteric coating system 93A 73mg;

[0065] Simethicone 0.73mg;

[0066] Glyceryl Triacetate 5mg.

[0067] Preparation method:

[0068] Weigh the prescribed amount of tablet core materials, mix them evenly, pass through a 100-mesh sieve, make a soft material with water, pass through a 24-mesh sieve, dry the obtained wet granules, and press into tablets. Weigh the prescribed amount of hypromellose, and disperse it with the prescribed amount of purified water to obtain the isolation layer. The enteric-coated layer material is weighed and dispersed with purified water to obtain the enteric-coated layer. Wrap the S-carboxymethyl-L-cysteine ​​tablet with the isolation layer and the enteric-coated layer in turn to obtain the S-carboxymethyl-L-cysteine ​​enteric-coated tablet.

Embodiment 3

[0070] Chip

[0071]

[0072] Isolation layer

[0073] Hypromellose 16mg;

[0074] Enteric layer

[0075] Waterborne acrylic enteric coating system 93A 73mg;

[0076] Simethicone 1mg;

[0077] Triethyl Citrate 10mg.

[0078] Preparation method:

[0079] Weigh the prescribed amount of tablet core materials, mix them evenly, pass through a 100-mesh sieve, make a soft material with water, pass through a 24-mesh sieve, dry the obtained wet granules, and press into tablets. Weigh the prescribed amount of hypromellose, and disperse it with the prescribed amount of purified water to obtain the isolation layer. The enteric-coated layer material is weighed and dispersed with purified water to obtain the enteric-coated layer. Wrap the S-carboxymethyl-L-cysteine ​​tablet with the isolation layer and the enteric-coated layer in turn to obtain the S-carboxymethyl-L-cysteine ​​enteric-coated tablet.

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Abstract

The invention provides an S-carboxymethyl-L-cysteine containing medicinal composition. The medicinal composition is an enteric tablet comprising a tablet core, an isolating layer and an enteric coating layer. The S-carboxymethyl-L-cysteine containing enteric tablet provided by the invention cannot be dissolved in the stomach and is low irritation to the stomach; the S-carboxymethyl-L-cysteine containing enteric tablet is dissolved in the small intestine as a main medicine absorbing site, improves the bioavailability of S-carboxymethyl-L-cysteine and is stable in quality during storage.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular, the invention relates to an enteric-coated tablet and a preparation method thereof. Background technique [0002] S-(carboxymethyl)-L-cysteine, also known as carboxycisteine, was first developed and used clinically by the French Joullie company in 1961. It is a mucolytic drug that can affect the secretion of bronchial glands. Increase the secretion of low-viscosity salivary mucin, reduce the production of high-viscosity fucoidal mucin, and directly act on the disulfide bond of mucin to crack mucin molecules to reduce the viscosity of sputum and make it easier to spit out ; Can improve mucociliary clearance; reduce airway hyperresponsiveness. After CMC enters the body, it is easy to remove the carboxymethyl group to form cysteine, and the sulfhydryl group contained in it can interact with electrophilic groups such as reactive oxygen species (ROS) to exert a dire...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/32A61K47/32A61K31/198A61P11/12A61P11/10
CPCA61K9/284A61K9/2886A61K31/198A61P11/10A61P11/12
Inventor 王玮王健松肖颖裴泽建朱少璇
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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