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Novel purpose of S-(carboxymethyl)-L-cysteine

A technology of cysteine ​​and carboxymethyl, which is applied in the field of new drug use of salt, can solve problems such as smog and haze diseases that have not been seen, and achieve the effect of improving oxidative stress

Inactive Publication Date: 2018-04-03
GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has not been any report on the use of smog to cause diseases

Method used

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  • Novel purpose of S-(carboxymethyl)-L-cysteine
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  • Novel purpose of S-(carboxymethyl)-L-cysteine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1 Preparation of tablet of the present invention

[0043] S-(carboxymethyl)-L-cysteine ​​500 g

[0044] Pregelatinized starch 500g

[0045] Magnesium Stearate 10g

[0046] Fully mix 500g of the above S-(carboxymethyl)-L-cysteine ​​and 500g of pregelatinized starch, add water to make a soft material, granulate, dry the whole material, add magnesium stearate, and press into tablets There are 1000 tablets in total, each containing 500mg of S-(carboxymethyl)-L-cysteine.

Embodiment 2

[0047] Embodiment 2 Preparation of granules of the present invention

[0048] S-(carboxymethyl)-L-cysteine ​​500 g

[0049] Pregelatinized starch 500g

[0050] Magnesium Stearate 10g

[0051] Fully mix 500g of the above-mentioned S-(carboxymethyl)-L-cysteine ​​and 500g of pregelatinized starch, make a soft material, granulate, dry, and bag after granulation, a total of 1000 bags, each bag contains S-(carboxymethyl)-L-cysteine ​​500mg.

Embodiment 3

[0052] Embodiment 3 Preparation of oral solution of the present invention

[0053] S-(carboxymethyl)-L-cysteine ​​500 g

[0054] Sucrose 500g

[0055] Flavor Appropriate amount

[0056] Add water to 1000mL

[0057] Fully mix and dissolve the above S-(carboxymethyl)-L-cysteine ​​500g, sucrose 500g and appropriate amount of essence, add water to 1000mL, divide into 10mL / bottles, 1000 bottles in total, each tablet contains S-(carboxymethyl) Methyl)-L-cysteine ​​500mg.

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PUM

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Abstract

The invention relates to a novel purpose of medicine, in particular to application of S-(carboxymethyl)-L-cysteine and pharmacologically acceptable salts of the S-(carboxymethyl)-L-cysteine to prevention and / or treatment of respiratory system diseases and the like caused by haze. The S-(carboxymethyl)-L-cysteine and the pharmacologically acceptable salts of the S-(carboxymethyl)-L-cysteine are used; and the inflammation damage and oxidation operation of atmosphere PM2.5 on the lungs of mice can be obviously reduced, so that the S-(carboxymethyl)-L-cysteine and the pharmacologically acceptablesalts of the S-(carboxymethyl)-L-cysteine can be applied to preparation of medicine for preventing and treating diseases caused by haze.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a new medicine application of S-(carboxymethyl)-L-cysteine ​​and a pharmaceutically acceptable salt thereof. Background technique [0002] The clinical manifestations of diseases caused by smog are not exactly the same as those of the same disease caused by other reasons. Taking COPD as an example, the smoke produced by the combustion of biofuels (including firewood, wood, charcoal, crop stalks and animal manure, etc.) is one of the main sources of smog ( Ran Pixin. The role of biofuels in the pathogenesis of chronic obstructive pulmonary disease should not be ignored. Chinese tuberculosis and respiratory Journal, 2010, 33(4): 241-242. ), the clinical features of COPD caused by it (referred to as "B-COPD") and smoking-induced COPD (referred to as "T-COPD") are very different. B-COPD patients are more common in women, with low body mass index (BMI) , more clinical...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K31/205A61P35/00A61P9/12A61P9/00A61P9/10A61P9/06A61P9/04A61P11/04A61P11/14A61P11/00A61P11/06A61P11/08A61P37/02A61P15/00
CPCA61K31/198A61K31/205
Inventor 王玮王健松裴泽健朱少璇
Owner GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY
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