Application of hydroxytyrosol in preparation of drug for preventing and treating Alzheimer disease

A technology for Alzheimer's disease and hydroxytyrosol, applied in the field of biomedicine, can solve problems such as the unclear pathogenesis of Alzheimer's disease, improve mitochondrial oxidative stress, repair nerve function damage, and improve Alzheimer's disease. silent sickness effect

Inactive Publication Date: 2016-11-23
XI AN JIAOTONG UNIV
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Problems solved by technology

[0003] At present, the specific pathogenesis of Alzheimer's disease is still unclear. Therefore, new methods of treating Alzheimer's disease are the direction of current researchers' efforts to study

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  • Application of hydroxytyrosol in preparation of drug for preventing and treating Alzheimer disease
  • Application of hydroxytyrosol in preparation of drug for preventing and treating Alzheimer disease
  • Application of hydroxytyrosol in preparation of drug for preventing and treating Alzheimer disease

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Embodiment Construction

[0024] The present invention will be further described in detail below in conjunction with specific embodiments, which are explanations of the present invention rather than limitations.

[0025] The present invention finds that after administration of hydroxytyrosol, hydroxytyrosol can cross the blood-brain barrier to increase the content of hydroxytyrosol in brain tissue, and significantly improve brain nerve function and learning and memory ability of Alzheimer's disease mice. Moreover, hydroxytyrosol can also reverse the mitochondrial dysfunction and abnormal mitochondrial protein carbonylation in the brain of Alzheimer's mice, increase the expression of SOD-2 protein, and then improve the homeostasis of the binomial enzyme system. More importantly, due to the long-term inflammatory damage in the brain of Alzheimer's disease, under the intervention of hydroxytyrosol, targeting JNK / MAPK, the inflammatory damage in the brain of Alzheimer's disease mice was significantly improv...

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Abstract

The invention discloses an application of hydroxytyrosol in preparation of healthy food and a drug for preventing and treating Alzheimer disease. Hydroxytyrosol can cross the blood brain barrier so as to remarkably improve cerebral nerve functions and learning and memory abilities of a mouse with the Alzheimer disease; besides, hydroxytyrosol can also reverse mitochondrial dysfunction and mitochondrial protein carbonylation abnormity in the brain of the mouse with the Alzheimer disease, SOD-2 protein expression is improved, and system steady states of two enzymes are improved. More importantly, due to the fact that the mouse with the Alzheimer disease has long-term inflammatory injury in the brain, the inflammatory injury in the brain of the mouse with the Alzheimer disease is remarkably relieved with JNK / MAPK (Jun N-terminal kinase / Mitogen-activated protein kinase) as a target under intervention of hydroxytyrosol, and the functions of preventing and treating occurrence and development of the Alzheimer disease are realized.

Description

technical field [0001] The technical field of biomedicine of the present invention relates to the application of hydroxytyrosol in the preparation of drugs for preventing and treating Alzheimer's disease. Background technique [0002] Alzheimer's disease, the main type of dementia, is the most prevalent neurodegenerative disease in the elderly population. Its onset is slow, and it deteriorates into persistent neurological dysfunction over time, causing many complications. The average life time after diagnosis is three to nine years, and patients gradually lose their physical functions, eventually leading to death. [0003] At present, the specific pathogenesis of Alzheimer's disease is still unclear. Therefore, new methods for treating Alzheimer's disease are the direction that researchers are working hard at present. Mitochondrial oxidative stress in the brain appears in the early stage of Alzheimer's disease and runs through the entire pathological process of Alzheimer's ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P25/28A23L33/10
CPCA61K31/05A23V2002/00A23V2200/322A23V2250/08
Inventor 龙建纲彭韵桦侯晨刘静时乐刘健康
Owner XI AN JIAOTONG UNIV
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