Vesicles for delayed delivery of fragrance their preparation and use thereof

A technology of vesicles and fragrances, which is applied in preparations for toiletry, formulations of perfume preparations, fragrances of washing compositions, etc.

Inactive Publication Date: 2020-09-11
CLARIANT INT LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Encapsulation of multiple fragrances with different partition coefficients, especially water-soluble fragrances, remains a challenge

Method used

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  • Vesicles for delayed delivery of fragrance their preparation and use thereof
  • Vesicles for delayed delivery of fragrance their preparation and use thereof
  • Vesicles for delayed delivery of fragrance their preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Phase A:

[0118] 2.5% by weight ethoxylated lauryl alcohol, degree of ethoxylation 23 (Brij L23)

[0119] 2.5% by weight ethoxylated stearyl alcohol, degree of ethoxylation 100 (Brij S100)

[0120] 2.5% by weight glycerin

[0121] 2.5% by weight water

[0122] Phase B:

[0123] 10% by weight cetyl palmitate (Cutina CP)

[0124] 10% by weight caprylic / capric triglycerides (Rotefan CCT)

[0125] 20% by weight fragrance

[0126] Phase C:

[0127] 0.05% by weight of methylchloroisothiazolinone (Kathon CG)

[0128] 49.5% by weight water

[0129] The components of phase A and phase B are introduced into the inlet line of the emulsification device disclosed in US 2013 / 0201785 A1. The product from this emulsifying device is a composition consisting essentially of multilamellar vesicles in spherical shape comprising two or more concentric lipid bilayers and perfume. The perfume loading is greater than 50% by weight, based on the total weight of the vesicle.

[0130] The product obtained from t...

Embodiment 2

[0133] Phase A:

[0134] 2% by weight of sodium salt of collagen hydrolysate modified with lauric acid (LameponS)

[0135] 2% by weight ethoxylated lauryl alcohol, degree of ethoxylation 23 (Brij L23)

[0136] 2% by weight ethoxylated stearyl alcohol, degree of ethoxylation 100 (Brij S100)

[0137] 2.5% by weight glycerin

[0138] 1.1% by weight water

[0139] Phase B:

[0140] 5 wt% cetyl palmitate (Cutina CP)

[0141] 10% by weight caprylic / capric triglyceride (Rotefan CCT)

[0142] 5 wt% polyvinyl acetate (Dodiflow 5599)

[0143] 20% by weight fragrance

[0144] Phase C:

[0145] 0.05% by weight of methylchloroisothiazolinone (Kathon CG)

[0146] 49.5% by weight water

[0147] The compositions of phases A and B are treated as in example 1 and the product obtained is diluted with phase C as described in example 1.

[0148] For Example 2, the average particle size measured with Horiba LA 940 was 173 nm and the standard deviation was 53 nm.

[0149] In addition, DSC (differential scanning calorime...

Embodiment 3

[0157] Example 3 (with higher amount of perfume in the composition)

[0158]

[0159] For Example 3, the average particle size measured with Horiba LA 940 was 184 nm and the standard deviation was 69 nm.

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Abstract

Disclosed is a multilamellar vesicle in the shape of a rotational body comprising two or more concentric lipid double layers and fragrance wherein the vesicle has a mean diameter between 100 and 800 nm, the lipid double layers comprise a) at least one surfactant having a HLB value of greater than 6, and b) an amphiphilic compound having a logP value of 1 or above, and wherein the vesicle comprisesin addition to components a) and b) a fragrance having a log P value of 1 or above. The fragrance is encapsulated in the vesicles. The encapsulated fragrance is stable during storage conditions and the vesicles have long-lasting fragrance release on use thereof. The vesicles may be used in cosmetic formulations or in laundry formulations.

Description

Technical field [0001] The present invention relates to multi-layered vesicles with high perfume loading and to their use in cosmetic preparations or in laundry applications. Background technique [0002] Many cosmetic and laundry compositions contain fragrances. These are usually mixed directly into compositions such as shampoos, body washes, facial cleansers, solid or liquid soaps or creams and lotions, and left on hair care products. The disadvantage of this procedure is that, in most cases, only a small amount of fragrance remains on the skin, hair or fabric during use, where it can perform their functions. Most fragrances are usually washed off during use. This results in having to introduce a large amount of expensive perfume into the formulation to obtain the desired effect. However, when an appropriately high amount of fragrance is used in cosmetic or clothing formulations, this may cause undesirable skin irritation when using the formulation. [0003] Spices are volati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61Q13/00A61Q19/10C11D3/50C11D1/722C11D1/83A61K8/39A61K8/37
CPCA61K8/37A61K8/375A61K8/39A61Q13/00A61Q19/10A61K8/14A61K2800/412A61K2800/56A61K2800/596C11D3/001C11D3/505C11D17/0039A61K8/0295C11D1/722C11D1/8305C11D3/507A61K8/42A61K8/463A61K8/466A61Q5/00
Inventor G·戴姆斯N·A·万格达雷
Owner CLARIANT INT LTD
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