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Application of Yiqing compound preparation to preparation of drugs for preventing/treating novel coronavirus infection

A compound preparation, coronavirus technology, applied in antiviral agents, resistance to vector-borne diseases, pharmaceutical formulations, etc., can solve problems such as no new coronavirus infection

Active Publication Date: 2020-10-16
THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But as of now, there is no specific drug for novel coronavirus infection

Method used

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  • Application of Yiqing compound preparation to preparation of drugs for preventing/treating novel coronavirus infection
  • Application of Yiqing compound preparation to preparation of drugs for preventing/treating novel coronavirus infection
  • Application of Yiqing compound preparation to preparation of drugs for preventing/treating novel coronavirus infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1: the application of Yiqing granules:

[0020] Yiqing granules can be purchased from the market, or can be prepared according to the preparation method of "Yiqing granules" on page 427 of "Chinese Pharmacopoeia" 2015 Edition, and the obtained granules can be directly used for the prevention / treatment of novel coronavirus infection disease. Usage and dosage: Oral, 6.5g / time, 3 times / day.

Embodiment 2

[0021] Example 2: Application of Yiqing compound preparation:

[0022] Weigh 165g of coptis rhizome, 500g of rhubarb rhubarb and 250g of scutellaria baicalensis, add water and decoct twice, the first time is 1.5 hours, the second time is 1 hour, combine the decoction, filter, the filtrate is concentrated under reduced pressure to 70°C and the relative density is 1.25, spray Dried into dry extract powder, the three extract powders are combined, and then various oral preparations are made by using the existing preparation molding process. The resulting Yiqing oral preparation can be used to prevent / treat novel coronavirus infectious diseases. Usage and dosage: Oral, 6.5g / time, 3 times / day.

Embodiment 3

[0023] Example 3: Application of Yiqing compound preparation:

[0024] Take Coptidis Rhizoma 165g, Rhizoma Rhizoma Rhizome 500g and Scutellaria baicalensis 250g, adopt conventional extraction process and formulation molding process to make various oral preparations. The obtained Yiqing oral preparation can be used to prevent / treat novel coronavirus infectious diseases. Usage and dosage: oral administration, 6.5g / time, 3 times / day.

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Abstract

The invention discloses an application of Yiqing compound preparation to preparation of drugs for preventing / treating novel coronavirus infection. The Yiqing compound preparation is prepared from bulkdrugs of rhizoma coptidis, radix et rhizoma rhei and radix scutellariae. A drug screening model for blocking novel coronavirus spike glycoprotein and target cell receptor angiotensin converting enzyme 2 (ACE2) is constructed, and the model shows that the Yiqing compound preparation has activity of inhibiting binding of novel coronavirus spike glycoprotein and target cell receptor ACE2 and inhibiting expression of TMPRSS2 (transmembrane protease serine 2) to prevent viruses from entering target cells, and can significantly inhibit production of inflammatory factors (IL-2, IL-6, etc.) by virus-infected cells. The Yiqing compound preparation can be applied to prevention and treatment of infectious diseases in novel coronavirus, provides a drug choice for novel coronavirus patients, and has great significance in current epidemic prevention and control.

Description

technical field [0001] The present invention relates to a new application of a medicine, specifically the application of a compound preparation of Yiqing in the preparation of a medicine for the prevention / treatment of novel coronavirus infection, which belongs to the technical field of traditional Chinese medicine application. Background technique [0002] Yiqing granule is a national medicine formula preparation, a Chinese patent medicine, which has the effect of clearing heat, purging fire and detoxifying; it is clinically used to treat red eyes and mouth sores, swelling and pain of throat and gums, constipation caused by fire, poison and blood heat; pharyngitis, tonsillitis, gum diseases such as inflammation. The main raw material ingredients include coptis, rhubarb, and skullcap medicinal materials. [0003] Coronaviruses are enveloped, single-stranded positive-sense RNA viruses that are widely found in human, mammalian, and avian hosts and can cause respiratory, intes...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P31/14
CPCA61K36/718A61K36/708A61K36/539A61P31/14A61K2236/331A61K2236/39A61K2300/00Y02A50/30
Inventor 李艳梅杨小生杨礼寿饶青宋晶睿邱剑飞杨珏
Owner THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
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