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Body fluid small molecule metabolic marker of zebra fish infected bacteria and application of marker

A zebrafish, small molecule technology, applied in applications, metabolic diseases, antibacterial drugs, etc., can solve problems such as unclear metabolome

Inactive Publication Date: 2020-10-30
HEZE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the metabolome involved in regulating the zebrafish immune response to bacterial infection is largely unknown

Method used

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  • Body fluid small molecule metabolic marker of zebra fish infected bacteria and application of marker
  • Body fluid small molecule metabolic marker of zebra fish infected bacteria and application of marker
  • Body fluid small molecule metabolic marker of zebra fish infected bacteria and application of marker

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Embodiment Construction

[0032] The present invention will be further described below in conjunction with embodiment. However, the scope of the present invention is not limited to the following examples. Those skilled in the art can understand that various changes and modifications can be made in the present invention without departing from the spirit and scope of the present invention.

[0033] The present invention provides general and / or specific descriptions of the materials and test methods used in the tests. While many of the materials and methods of manipulation which are employed for the purposes of the invention are well known in the art, the invention has been described here in as much detail as possible.

[0034] The instruments, reagents, materials, etc. involved in the following examples, unless otherwise specified, are conventional instruments, reagents, materials, etc. in the prior art, and can be obtained through formal commercial channels. The experimental methods, detection methods...

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Abstract

The invention discloses a body fluid micromolecular metabolic marker of zebra fish infected bacteria, and the marker is at least one of glutamine, lactic acid, serine and glycine, preferably glutamine. The bacteria are selected from vibrio parahaemolyticus. The invention also discloses an application of glutamine in improving the immunity of zebra fish responding to vibrio parahaemolyticus infection, an application of glutamine in preparing medicines or health care products for improving the immunity of zebra fish responding to vibrio parahaemolyticus infection, an application of glutamine inregulation and control of galactose metabolism of zebra fish, and an application of glutamine in regulation and control of a biosynthetic metabolic pathway of aminoacyl tRNA of zebra fish. It is foundthrough experiments that glutamine plays an important role in zebra fish responding to bacterial infection, plays an extremely important role in zebra fish innate immune response, and can be used forresearch of metabolome functions, detection and treatment of zebra fish infected bacteria and the like. The marker has high reference value for research of metabonomics related to zebra fish responseto bacterial infection immune response.

Description

technical field [0001] The invention relates to a zebrafish-responsive bacterial small molecule metabolism marker and an application thereof, belonging to the technical field of biomarkers. Background technique [0002] Metabonomics (metabonomics / metabolomics) is a research method that imitates the research ideas of genomics and proteomics, conducts quantitative analysis of all metabolites in organisms, and searches for the relative relationship between metabolites and physiological and pathological changes. component. Most of its research objects are small molecular substances with a relative molecular mass of less than 1000. Metabolome refers to all low-molecular-weight metabolites of a certain organism or cell in a specific physiological period, and metabolomics is the simultaneous qualitative and quantitative analysis of all low-molecular-weight metabolites of a certain organism or cell in a specific physiological period It is a branch of systems biology based on the a...

Claims

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Application Information

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IPC IPC(8): G01N33/68A61K31/401A61K31/198A61P31/04A61P37/04A23L33/175A61K31/325A61P37/00A61P3/00
CPCA23V2002/00A61K31/198A61K31/325A61K31/401A23L33/175A61P3/00A61P31/04A61P37/00A61P37/04G01N33/6893G01N2800/7095A23V2200/324
Inventor 张海丽郭燕风钊鹏赵嘉豪赵源
Owner HEZE UNIV
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