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Composite material as well as preparation method and application thereof

A technology for composite materials and tooth restoration, which is applied in the field of composite materials for oral tooth restoration. It can solve problems such as easy shedding, inability to provide long-term stable drug release, lack of adhesive groups in the film, etc., and achieve continuous mineralization restoration. Effect

Active Publication Date: 2020-12-01
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The film lacks adhesive groups, cannot form a firm bond with the tooth surface, is easy to fall off, and cannot provide long-term and stable drug release

Method used

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  • Composite material as well as preparation method and application thereof
  • Composite material as well as preparation method and application thereof
  • Composite material as well as preparation method and application thereof

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Embodiment Construction

[0022] The preparation method of the composite material for dental restoration according to an exemplary embodiment of the present disclosure includes: combining the phenolic hydroxyl group of tannic acid with the amide bond of silk fibroin and the amide bond of 8DSS to form a hydrogen bond, and synthesizing a composite Material (TA-SF-8DSS), wherein, 8DSS comprises 8 repeated sequences of aspartic acid-serine-serine polypeptide sequence.

[0023] Among them, tannic acid (TA) is a polyphenolic compound extracted from plants, which is one of the water-soluble hydrolyzed tannins, and widely exists in fruits, vegetables, nuts, tea and coffee. TA is rich in catechol structure and has strong water phase adhesion ability. However, the excellent water solubility of TA makes it easy to be eluted by water when it is used as a wet adhesion material. Therefore, the co-assembly of tannins with other polymers is beneficial for the design and synthesis of bioadhesives and exerts the antiba...

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Abstract

The invention provides a composite material as well as a preparation method and application thereof. The preparation method comprises the steps that phenolic hydroxyl of tannic acid, an amido bond ofsilk fibroin and an amido bond of 8DSS are combined to form hydrogen bonds, a composite material is synthesized, and 8DSS comprises an aspartic acid-serine-serine polypeptide sequence of eight repetitive sequences. According to the present invention, a wet adhesion material is adopted as a carrier, the bionic remineralization function is provided for the material, the material can be adhered to aneck tooth tissue in the wet environment, the strong interface bonding force can be maintained, the influence of saliva and gingival crevicular fluid can be resisted, and the remineralization can be continuously promoted so as to achieve the purposes of prevention, termination and repair of tooth neck lesions.

Description

technical field [0001] The technical field of the disclosed materials, more specifically, relates to a composite material for dental restoration, a preparation method and application of the composite material. Background technique [0002] Dental and cervical diseases, mainly referring to cervical caries, root caries, wedge-shaped defects, etc., are common and frequently-occurring diseases in oral clinics, accounting for more than half of the daily dental clinics. Dental neck disease spreads around the dentin in the neck, causing tooth defects, residual crowns and roots, and has become a serious problem that plagues the oral and general health of middle-aged and elderly people. [0003] The lesions of dental neck diseases are mostly located at the gingival margin or subgingival, and are always in the wet environment of saliva and gingival crevicular fluid. It is difficult to completely control the moisture in the oral treatment of this area; dentin is the main structure of t...

Claims

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Application Information

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IPC IPC(8): A61K6/20A61K6/80
CPCA61K6/20A61K6/80C08L89/00
Inventor 李继遥杨佼佼甄理梁坤能袁鹤侯嫒琳
Owner SICHUAN UNIV
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