The present application discloses a mineralization material for treating
dentin hypersensitivity and promoting epitaxial growth of enamel, and its use, which comprises, by weight, 5-72 parts of a membrane-forming
protein or PEGylated membrane-forming
protein, 4-67 parts of a water-soluble disulfide exchanger, and 1-21 parts of a pH adjuster. The present application first proposes using a non-toxic disulfide exchanger (e.g.,
cysteine (Cys)) to react with a membrane-forming
protein or PEGylated membrane-forming protein, so that when a protein nano-
coating layer with a mineralization-regulating function is formed, a large amount of high molecular weight protein aggregates that block
dentin pores are not generated, the permeability is better, and the protein nano-
coating layer can penetrate deeper into the already exposed
dentin pores, reaching a depth of 200-500 μm (the blocking depth of the protein
coating layer reacting with
TCEP is only about 40 μm), and can reach the recesses of pits and fissures.