Disclosed are oral care compositions comprising selected surface-active 
organophosphate compounds and methods of use to provide protection of teeth from 
erosion caused by the action of chemicals, such as harsh abrasives and acids. The surface-active 
organophosphate compounds are substantive to teeth, the 
phosphate groups binding the 
calcium in teeth and thus preventing loss of 
calcium from 
dissolution when contacted with acids. The 
organophosphate compound may also deposit a protective 
surface coating that prevents contact of teeth with erosive challenges. Selected organophosphate compounds contain one or more 
phosphate groups and are combined in the oral care composition with one or more of a 
fluoride ion agent, an 
antimicrobial agent preferably selected from 
quaternary ammonium compounds and polyvalent 
metal salts, an anticalculus agent and additional surfactant, to provide benefits including superior anti-
erosion, anticaries, antiplaque and anti-
staining as demonstrated by enhanced 
fluoride uptake, remineralization, resistance to acid 
demineralization and 
antimicrobial activities, resulting in improved overall tooth health, 
structural integrity and appearance.