Nicotinamide mononucleotide sustained-release pellets and preparation method thereof

A technology of sustained-release pellets and mononucleotides, which can be applied to microcapsules, pharmaceutical formulations, active ingredients of anhydrides/acids/halides, etc., and can solve problems such as difficult access and low safety

Pending Publication Date: 2020-12-18
深圳深刻实验室有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the above problems that are difficult to achieve long-term, stable effects and low safety, the present invention proposes the following solutions

Method used

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  • Nicotinamide mononucleotide sustained-release pellets and preparation method thereof
  • Nicotinamide mononucleotide sustained-release pellets and preparation method thereof
  • Nicotinamide mononucleotide sustained-release pellets and preparation method thereof

Examples

Experimental program
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Embodiment Construction

[0011] In a first aspect, the present invention provides a sustained-release pellet.

[0012] The invention relates to a sustained-release pellet, which comprises: a blank pellet core, a drug-containing layer and a sustained-release layer. The drug-containing layer includes nicotinamide mononucleotide, taurine, riboflavin sodium phosphate, methionine and a binder.

[0013] Relative to the total weight of the sustained-release pellets, the content of the nicotinamide mononucleotide may be 40.0wt%-60.0wt%. In some embodiments, relative to the total weight of the sustained-release pellets, the content of the nicotinamide mononucleotide is 42.0wt%-48.0wt%. In some embodiments, relative to the total weight of the sustained-release pellets, the content of the nicotinamide mononucleotide is 44.0wt%-46.0wt%. In some embodiments, relative to the total weight of the sustained-release pellets, the content of the nicotinamide mononucleotide is 45.0wt%.

[0014] Relative to the total we...

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Abstract

The invention relates to nicotinamide mononucleotide sustained-release pellets and a preparation method thereof, and belongs to the field of medicine / health-care product preparations. The sustained-release pellets contain nicotinamide mononucleotide, taurine, riboflavin sodium phosphate, methionine, an adhesive and other substances, can safely, stably and permanently exert anti-aging and anti-oxidation effects, and also can promote metabolism of nicotinamide accumulated in the body, and multiple components cooperate with one another and are more effective than single use. The method is simpleto operate, low in cost and suitable for industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical / health product preparations, in particular to a nicotinamide mononucleotide sustained-release pellet and a preparation method thereof. Background technique [0002] Nicotinamide mononucleotide (NMN, nicotinamide mononucleotide), which belongs to the precursor of NAD, provides such NAD+ precursors with preventive and therapeutic effects, alleviates age-related pathology and disease states, and has metabolic benefits, enhancing SIRTs family, decreased expression of inflammation-related genes, decreased oxidative stress, and improved cardiac rhythm, decreased age-related inflammation in adipose tissue, and improved systemic insulin sensitivity. Existing research results have shown that NMN can promote mitochondrial function, including promoting the ability of mitochondrial oxidative phosphorylation and increasing mitochondrial lipid oxidation. Promotes the function of the nervous system, including impr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/62A61K9/58A61K31/706A61P25/28A61P39/06A61K31/675A61K31/185
CPCA61K31/706A61K31/185A61K31/675A61K9/5078A61P39/06A61P25/28A61K2300/00
Inventor 王江懿
Owner 深圳深刻实验室有限公司
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