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Nicotinamide mononucleotide sustained-release enteric orally disintegrating tablet and preparation method thereof

An enteric-coated tablet and sustained-release technology, which is used in pharmaceutical formulations, medical preparations containing active ingredients, and pill delivery, etc., can solve problems such as low safety, poor stability, and difficulty in taking

Inactive Publication Date: 2020-12-29
深圳深刻实验室有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the above-mentioned problems such as short action time, poor stability, low safety, and difficulty in taking, the present invention proposes the following solutions

Method used

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  • Nicotinamide mononucleotide sustained-release enteric orally disintegrating tablet and preparation method thereof
  • Nicotinamide mononucleotide sustained-release enteric orally disintegrating tablet and preparation method thereof
  • Nicotinamide mononucleotide sustained-release enteric orally disintegrating tablet and preparation method thereof

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Embodiment Construction

[0011] In the first aspect, the present invention provides a sustained-release enteric-coated orally disintegrating tablet.

[0012] A sustained-release enteric-coated orally disintegrating tablet, the sustained-release orally-disintegrating enteric-coated tablet comprises enteric-coated sustained-release microspheres and pharmaceutically acceptable excipients; the enteric-coated sustained-release microspheres comprise active ingredients, enteric carriers and Enteric coating material; the active ingredient includes at least one of nicotinamide mononucleotide, curcumin, coenzyme Q10 or folic acid.

[0013] In some embodiments the active ingredients are nicotinamide mononucleotide, curcumin, coenzyme Q10 and folic acid.

[0014] The enteric sustained-release microspheres may also contain plasticizers, stabilizers and release modifiers.

[0015] Relative to the total weight of the active ingredient, the content of the nicotinamide mononucleotide may be 50.00wt%-80.00wt%. In som...

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Abstract

The invention relates to a nicotinamide mononucleotide sustained-release enteric-coated orally disintegrating tablet and a preparation method thereof, and belongs to the field of medicine / health-careproduct preparations. Active ingredients of the sustained-release enteric orally disintegrating tablet comprise at least one of nicotinamide mononucleotide, curcumin, coenzyme Q10 or folic acid. The sustained-release enteric orally disintegrating tablet is easy to take, can safely, stably and permanently play anti-aging and anti-oxidation effects, can be released after the medicine reaches intestinal tracts, avoiding damage of acidic conditions to active ingredients.The active ingredients can play a synergistic effect with each other, which is more effective than using them alone. The method is simple in preparation, the prepared sustained-release enteric orally disintegrating tablet has good sustained-release property and good taste, and the method is low in cost and suitable for industrial production.

Description

technical field [0001] The present invention relates to the field of pharmaceutical / health product preparations, in particular to a nicotinamide mononucleotide slow-release enteric-coated orally disintegrating tablet and a preparation method thereof. Background technique [0002] Nicotinamide mononucleotide (NMN, nicotinamide mononucleotide), which belongs to the precursor substance of nicotinamide adenine dinucleotide, provides this kind of NAD+ precursor substance with preventive and therapeutic effects, and relieves age-related pathological and disease states. As well as metabolic benefits, enhancing the activity of the SIRTs family, reducing the expression of inflammation-related genes, reducing oxidative stress, and improving cardiac rhythm, reducing age-related inflammation in adipose tissue, and improving systemic insulin sensitivity. NMN can promote mitochondrial function, including promoting mitochondrial oxidative phosphorylation ability, increasing mitochondrial l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/52A61K31/706A61K31/12A61K31/122A61K31/519A61P39/06
CPCA61K9/0056A61K9/2095A61K9/2081A61K9/5015A61K31/706A61K31/12A61K31/122A61K31/519A61P39/06A61K2300/00
Inventor 王江懿
Owner 深圳深刻实验室有限公司
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