Method for determining content of cisatracurium besilate for injection by using high performance liquid chromatograph
A technology of cisatracurium besylate and high performance liquid chromatography, applied in the field of medicine, can solve the problems of difficult analysis, mismatch between inspection time and production time, and many impurities, so as to reduce environmental pollution and shorten content determination time. , the effect of reducing the discharge volume
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[0025] The chromatographic conditions of the present invention are as follows: adopt ultra-high performance liquid chromatography (UPLC), use octadecyl bonded silica gel as a filler; -Acetonitrile (75:5:20) as mobile phase A, with 1.02% potassium dihydrogen phosphate buffer solution (adjust the pH value to 3.1 with phosphoric acid)-methanol-acetonitrile (50:30:20) as mobile phase B, press Table 2 carries out gradient elution; the detection wavelength is 280nm; the flow rate is 1.0ml / min.
[0026] Table 2 Gradient elution table of mobile phase A and mobile phase B
[0027]
[0028] Operation steps of the present invention are as follows:
[0029] 1. Preparation of the test solution: Take 10 bottles of this product, place each in a 25ml measuring bottle, dissolve it with mobile phase A and adjust the volume to the mark, shake well, and make a solution containing about 0.2mg of cisatracurium per 1ml , as the test solution, a total of 10 samples were prepared;
[0030] 2. Pr...
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