Application of transferrin and transferrin combined sodium oligomannate capsule and composition containing sodium oligomannate capsule

A transferrin and mannate sodium technology, applied in the direction of transferrin, drug combination, peptide/protein composition, etc., can solve problems such as unclear mechanism of action

Pending Publication Date: 2021-01-12
江苏豪思睦可生物科技有限公司
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Problems solved by technology

The mechanism of action in this animal model is unclear

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  • Application of transferrin and transferrin combined sodium oligomannate capsule and composition containing sodium oligomannate capsule
  • Application of transferrin and transferrin combined sodium oligomannate capsule and composition containing sodium oligomannate capsule
  • Application of transferrin and transferrin combined sodium oligomannate capsule and composition containing sodium oligomannate capsule

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preparation example Construction

[0043] The preparation method of described transferrin is as follows:

[0044] The following steps are sequentially included: preparation of pretreatment liquid, purification by hydrophobic chromatography, concentration and replacement.

[0045] Step 1. Preparation of pretreatment solution: the purpose of this step is to redissolve the protein in the precipitated human plasma CohnIV fraction, remove the filter aid, and remove some miscellaneous proteins after reconstitution.

[0046] Sub-step 1, the first reconstitution treatment: dissolve the solid CohnIV component into PBS buffer, mix well, and obtain the first reconstitution solution.

[0047] The mass volume ratio (w / v) of the above-mentioned human plasma CohnIV component to the PBS buffer is 1: (2-10), preferably 1:3.5; the above-mentioned PBS buffer is: 10-50mmol / LPBS, pH6.0- 8.0, preferably 20 mmol / LPBS, pH 7.5.

[0048] Sub-step 2, the first centrifugation treatment: centrifuge the above-mentioned first complex solut...

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Abstract

The invention provides application of transferrin and transferrin combined sodium oligomannate capsule and composition containing the sodium oligomannate capsule, and in particular relates to application of the transferrin or the transferrin combined sodium oligomannate capsule to preparation of a medicine for preventing or / and improving or / and treating dementia. and the composition containing thesodium oligomannate capsule comprises the sodium oligomannate capsule and the transferrin. The invention has the beneficial effects that the transferrin can improve the cognitive level of a dementiapatient, and with the combined use of the transferrin and the sodium oligomannate capsule, the effect of the sodium oligomannate capsule to prevent, improve and treat Alzheimer's disease and other types of dementia, such as vascular dementia, frontotemporal dementia, lewy body dementia,dementia caused by brain traumas and dementia caused by neuroinflammation, is further improved.

Description

technical field [0001] The invention belongs to the application field of biological medicines, and in particular relates to transferrin and the combined use of transferrin and manlute sodium capsules. Transferrin can improve the cognitive level of patients with dementia. Further improve the effect of Mannute Sodium Capsules in treating Alzheimer's disease and other types of dementia. Background technique [0002] Mannate Sodium Capsules (GV-971, trade name "Nine Phase One") is a low-molecular-weight acidic oligosaccharide compound extracted from marine brown algae. The drug is my country's original and the world's first new drug for the treatment of Alzheimer's disease (AD) targeting the brain-gut axis. Mannate Sodium Capsules has been conditionally approved for marketing due to its excellent safety. Previously, the world's treatment of AD mainly relied on five previously marketed drugs, all of which were mainly aimed at delaying the progression of mid-to-early symptoms of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/40A61K31/702A61P25/28C07K14/79C07K1/20C07K1/30C07K1/36C07K1/14
CPCA61K38/40A61K31/702A61P25/28C07K14/79A61K2300/00
Inventor 栗琳谢蓝崔雅轩张丽丽潘媛媛肖冰心丁亮
Owner 江苏豪思睦可生物科技有限公司
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