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Cell screening device and cell screening method

A screening device and screening method technology, applied in the field of cell screening, can solve the problems of low effective number of screening results, poor integrity and applicability, etc., to ensure the quality of screening results and the efficiency of screening operations, expand the scope, and facilitate subsequent processing operations. Effect

Pending Publication Date: 2021-02-02
SUZHOU SINGLERON BIOTECHNOLOGIES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a cell screening device and cell screening method to solve the problems of small effective number of screening results and poor integrity and applicability

Method used

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  • Cell screening device and cell screening method
  • Cell screening device and cell screening method
  • Cell screening device and cell screening method

Examples

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Embodiment 1

[0046] Such as Figure 1-Figure 3As shown, this embodiment provides a cell screening device, including a first chip 1 and a second chip 2, a plurality of first blind holes 11 are opened on one side of the first chip 1, and each first blind hole 11 is used for Collect a microbead or cell; one side of the second chip 2 is provided with a plurality of second blind holes 21, and when the second chip 2 and the first chip 1 are stacked, the second blind holes 21 and the first blind holes 11 are one by one It is set correspondingly, and the diameter of the second blind hole 21 is larger than the diameter of the first blind hole 11 . After the first chip 1 and the second chip 2 are superimposed, flip the first chip 1 and the second chip 2, so that the second chip 2 is placed on the top, and the microbeads or cells in the first blind hole 11 will enter the corresponding one due to their own weight. In the second blind hole 21 provided. Injecting the solution with microbeads into the ...

Embodiment 2

[0071] Such as Figure 6-8 As shown, the cell screening device of the second embodiment is basically the same as the first embodiment above, the difference between the two is that the cell screening device also includes at least one positioning member, and at least one first positioning hole 12 is opened on the first chip 1, At least one second positioning hole 22 is opened on the second chip 2. When the second chip 2 is stacked with the first chip 1, the first positioning hole 12 and the second positioning hole 22 are provided in one-to-one correspondence, and the positioning member passes through the second positioning hole 22. A positioning hole 12 and a second positioning hole 22 are used for positioning the first chip 1 and the second chip 2 . The setting of the first positioning hole 12 and the second positioning hole 22 facilitates the positioning operation of the first chip 1 and the second chip 2, and the first blind hole 11 can be realized by adjusting the positions ...

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Abstract

The invention relates to the technical field of cell screening, and particularly discloses a cell screening device and a cell screening method. The cell screening device comprises a first chip and a second chip, wherein a plurality of first blind holes are formed in one side of the first chip, and each first blind hole is used for collecting a microbead or a cell; and one side of the second chip is provided with a plurality of second blind holes, when the second chip and the first chip are overlapped, the second blind holes and the first blind holes are formed in a one-to-one correspondence mode, and the diameter of each second blind hole is larger than that of each first blind hole. According to the device, while the cell screening effect is improved, the range of the cell screening sizeis expanded, so that the effective number of screening results is increased, and the integrity and applicability are guaranteed.

Description

technical field [0001] The invention relates to the technical field of cell screening, in particular to a cell screening device and a cell screening method. Background technique [0002] In the prior art, a biochip is often used as a device for cell screening. Microbeads are arranged in the micropores on the biochip. With the help of the capture ability of the microbeads, the operation of separating a single cell or bacterial strain from a solution can be realized. Biochips are often used in high-throughput single-cell sequencing applications and single-cell capture. [0003] High-throughput single-cell microwell sequencing utilizes the structural design of microwells. One cell and one microbead with a specific molecular label can be captured in one well at the same time. Under the interactive reaction, the ribonucleic acid in the cell will dissociate from the cell and be captured by microbeads with molecular labels, and tens of thousands of microporous chips form tens of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00
CPCC12M47/04
Inventor 季艺邱匀彦方南
Owner SUZHOU SINGLERON BIOTECHNOLOGIES LTD
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