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Application of protein long-acting preparation in improving sexual dysfunction

A technology for improving sexual function and protein, which can be used in peptide/protein components, medical preparations containing active ingredients, sexual diseases, etc., and can solve problems such as inability to treat ED organic lesions

Pending Publication Date: 2021-03-05
XINTRUM PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chemical drugs used in the prior art for the treatment of ED, such as sildenafil citrate, can only temporarily restore abnormal erectile function to normal, and cannot treat the organic disease causing ED

Method used

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  • Application of protein long-acting preparation in improving sexual dysfunction
  • Application of protein long-acting preparation in improving sexual dysfunction
  • Application of protein long-acting preparation in improving sexual dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] In the following examples, the "ZX1305 protein" refers to the protein whose amino acid sequence is shown in SEQ ID NO.1. Example 1 ZX1305 Protein Sustained Release Preparation Experimental Study on Improving ED in Rats

[0020] 1 Experimental animals, experimental materials and instruments

[0021] 1.1 Experimental animals

[0022] 40 SPF grade male SD rats were provided by Qinglong Mountain Animal Breeding Farm, Jiangning District, Nanjing.

[0023] After 40 male SD rats were fed adaptively for 3 days, 10 rats were randomly selected as a blank control group of normal animals and fed with normal diet, and the remaining 30 rats were fed with high-fat diet to establish a diabetes model.

[0024] In the 4th week, rats in the blank control group of normal animals were given citric acid-sodium citrate buffer as a control;

[0025] Rats fed with high-fat diet were intraperitoneally injected with STZ solution (the dose was 60 mg / kg, and the solvent was citric acid-sodium ci...

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Abstract

The invention discloses a protein with an amino acid sequence as shown in SEQ ID NO. 1 or SEQ ID NO: 2 and a long-acting preparation prepared from a modified protein of the protein. The long-acting preparation has a function of improving sexual dysfunction. The modified protein is formed by connecting protein molecules with other proteins or connecting the protein molecules with other chemical substances.

Description

technical field [0001] The invention relates to the use of a long-acting protein preparation for improving sexual dysfunction. Background technique [0002] Erectile dysfunction (hereinafter referred to as ED) is the most common male sexual dysfunction. Its etiology can be divided into: psychosocial ED, organic ED (including vascular causes, neurological causes, etc.), or mixed ED (referring to erectile dysfunction caused by both psychosocial factors and organic causes). [0003] Medication is one of the ways to improve ED. The chemical drugs used in the prior art for treating ED, such as sildenafil citrate, can only temporarily restore abnormal erectile function, but cannot treat the organic disease leading to ED. [0004] Since ED has a high incidence and is a chronic disease, it is necessary to develop new long-acting drugs that can improve ED by reversing organic lesions. Contents of the invention [0005] The purpose of the present invention is to find a long-actin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61P15/10
CPCA61K38/1709A61P15/10A61K38/17C07K14/00
Inventor 张怡陈海廖高勇
Owner XINTRUM PHARMA
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