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Application of curculigoside in preparation of medicines for treating periprosthetic osteolysis

A technology of periprosthetic bone and curculigoside, which is applied in the directions of drug combination, bone disease, medical formula, etc., can solve the problems of lack of drug treatment and curculigoside treatment.

Pending Publication Date: 2021-04-30
HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, for the periprosthetic osteolysis caused by wear particles after artificial joint replacement, there is still a lack of effective drug treatment, and there is no report that curculigoside treats periprosthetic osteolysis, and the present invention comes from this

Method used

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  • Application of curculigoside in preparation of medicines for treating periprosthetic osteolysis
  • Application of curculigoside in preparation of medicines for treating periprosthetic osteolysis
  • Application of curculigoside in preparation of medicines for treating periprosthetic osteolysis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] Part I: Animal Experimentation

[0028] TRAP staining

[0029] 1 experimental animal

[0030] SPF grade female C57BL / 6 mice, weighing 20-30g. Provided by Shanghai Xipuer-Bikay Experimental Animal Co., Ltd., animal production license number SCXK (Shanghai) 2018-0008.

[0031] Breeding conditions: constant temperature, temperature 22±2°C, humidity 50%-60%, light alternates between light and dark every 12 hours, and air change frequency 15-20 times / hour. Raised by the Animal Experimental Research Center of Zhejiang University of Traditional Chinese Medicine. The license number of the experimental feeding room is SYXK (Zhejiang) 2018-0012.

[0032] 2 Experimental instruments and reagents

[0033] Table 2.1 Experimental Instruments

[0034]

[0035] Table 2.2 Experimental Reagents

[0036]

[0037] 3 Experimental methods

[0038] 3.1 Animal grouping and administration

[0039] A: Sham operation group (only sham operation is performed);

[0040] B: Ti particle...

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Abstract

The invention belongs to the technical field of new application of medicines, discloses application of curculigoside in medicines for treating periprosthetic osteolysis, and particularly relates to application of curculigoside in medicines for treating periprosthetic osteolysis after artificial joint replacement. The invention proves that curculigoside can inhibit osteoclast proliferation and differentiation induced by wear particles, inhibit osteoclast bone resorption activity and osteolytic cytokine release in an in-vitro cell environment, and has a certain prevention and treatment effect on periprosthetic osteolysis after artificial prosthesis replacement. The invention can be used as a new means for drug intervention of periprosthetic osteolysis after artificial prosthesis replacement.

Description

technical field [0001] The invention belongs to the technical field of new uses of medicines, and relates to the medicine use of curculinin, in particular to the use of curculinin in the preparation of medicines for treating periprosthetic osteolysis. Background technique [0002] Total joint arthroplasty (TJA) is one of the most successful orthopedic surgeries in the 20th century, which can effectively relieve joint pain, reconstruct joint function and improve the quality of life of patients. In 2007, a review article was published in "Lacent", calling TJA "the operation of the century". According to statistics, in the United States, about 700,000 patients receive TJA each year, and it is estimated that by 2030, more than 4 million patients will receive TJA each year. However, with the wide application of this technology and the prolongation of the service life of the prosthesis, the problem of prosthesis loosening becomes more and more serious. At present, aseptic loosen...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P19/08
CPCA61K31/7034A61P19/08
Inventor 朱芳兵全仁夫侯桥何春倪月明章英良
Owner HANGZHOU CITY XIAOSHAN DISTRICT TRADITIONAL CHINESE MEDICAL HOSPITAL
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