Application of methyleugenol in preparation of medicine for relieving hepatic ischemia-reperfusion injury

A technology of methyl eugenol and reperfusion injury, which is applied in the field of medicine to achieve the effect of reducing injury

Pending Publication Date: 2021-09-17
宫念樵
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there is no report or record of ME on redu

Method used

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  • Application of methyleugenol in preparation of medicine for relieving hepatic ischemia-reperfusion injury
  • Application of methyleugenol in preparation of medicine for relieving hepatic ischemia-reperfusion injury
  • Application of methyleugenol in preparation of medicine for relieving hepatic ischemia-reperfusion injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] 1. Partial liver ischemia-reperfusion injury model establishment

[0022] Male C57BL / 6J mice (weight 20g-22g) were used in the experiment. Mice were randomly divided into Sham (sham group), LIRI group, LIRI+Vehicle group and LIRI+ME group. Mice in LIRI+ME group were intragastrically administered ME 6 h before liver ischemia, while mice in LIRI+Vehicle group were intragastrically administered the same corn oil before ischemia. To determine the optimal concentration of ME, mice were set up at 3 different concentrations (6 mg / kg, 3 mg / kg, 1.5 mg / kg, Selleck, S5755) and screened by serum aminotransferase results. A sham-operated mouse model of partial hepatic ischemia-reperfusion injury was prepared as previously described and performed the same operation without clamping the blood vessels. Experimental design such as figure 1 As shown, the experiment was divided into four groups: Sham (sham operation group), LIRI (liver ischemia-reperfusion injury group), LIRI+Vehicle (...

Embodiment 2

[0039]This embodiment provides a pharmaceutical composition containing methyl eugenol for reducing liver ischemia-reperfusion injury. The pharmaceutical composition can also be made into acceptable pharmaceutical preparations, which include injections, oral preparations, powder injections, gels, capsules and patches; the content of methyl eugenol in the pharmaceutical preparation is more than 80% .

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Abstract

The invention provides an application of methyleugenol in preparation of a medicine for relieving hepatic ischemia-reperfusion injury. The methyleugenol comprises a medicine composition containing the methyleugenol and various pharmaceutically acceptable medicine preparations of the methyleugenol, has a protection effect on the hepatic ischemia-reperfusion injury, can relieve injury. The application of the methyleugenol in preparation of the medicine for relieving the hepatic ischemia-reperfusion injury has clinical practical significance and value for further development and application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of methyl eugenol in the preparation of a medicine for alleviating liver ischemia-reperfusion injury. Background technique [0002] Liver ischemia-reperfusion injury (LIRI) is a pathophysiological phenomenon during liver surgery. It causes a severe inflammatory response and cell death, ultimately leading to severe liver damage. LIRI is one of the main causes of clinical liver injury. It frequently occurs in liver resection, liver transplantation, and shock, and is one of the key factors leading to higher postoperative morbidity and mortality. During LIRI, there is an intense inflammatory process and apoptosis in the liver. This liver inflammation is characterized by an abundance of inflammatory mediators and inflammatory cells. Microvascular and sinusoidal endothelial cells are damaged due to neutrophil infiltration, deteriorating tissue condition...

Claims

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Application Information

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IPC IPC(8): A61K31/09A61P1/16
CPCA61K31/09A61P1/16
Inventor 宫念樵
Owner 宫念樵
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