SNP (Single Nucleotide Polymorphism) sites related to coronary heart disease and application thereof

A technology of coronary heart disease and locus, applied in SNP locus and its application field, can solve the problem that coronary heart disease is not clearly explained.

Pending Publication Date: 2021-11-12
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although a large number of susceptibility genes for coronary heart disease have been discovered through genetic research, these susceptibility genes can only explain about 28% of the heritability of coronary heart disease, and the heritability of coronary heart disease is as high as 40% through

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • SNP (Single Nucleotide Polymorphism) sites related to coronary heart disease and application thereof
  • SNP (Single Nucleotide Polymorphism) sites related to coronary heart disease and application thereof
  • SNP (Single Nucleotide Polymorphism) sites related to coronary heart disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment example

[0107] Two newly discovered SNP loci on the IL5 gene are associated with susceptibility to coronary heart disease (case-control analysis): 1863 samples from the Chinese Han population with coronary heart disease and 1920 samples from healthy controls were selected for the study, and clinical data and peripheral blood samples were collected , using the BloodGenMini Kit blood gene column small extraction kit provided by Kangwei Century to extract the whole genome DNA.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention belongs to the field of biotechnology research, and discloses SNP (Single Nucleotide Polymorphism) sites related to coronary heart disease and application thereof. The invention specifically relates to application of an IL5 gene rs2069812 site or an IL5 gene rs2057687 site in preparation of drugs for examining and screening coronary heart diseases, wherein the coronary heart diseases comprise myocardial infarction and angina pectoris; the invention further discloses application of a detection reagent for the rs2069812 site of the IL5 gene and/or the rs2057687 site of the IL5 gene in preparation of drugs for examining and screening the coronary heart disease; the invention further discloses application of allelotype significantly associated with coronary heart disease susceptibility in preparation of drugs for coronary heart disease examination and screening; and the invention further discloses application of low-risk allele of the coronary heart disease in preparation of drugs for examining and screening the coronary heart disease. According to the site, a new coronary heart disease detection site is found, different risk levels are found for different alleles, and a new scheme is provided for subsequent diagnosis and prevention of coronary heart disease.

Description

technical field [0001] The invention belongs to the field of biotechnology research, and particularly relates to SNP sites related to coronary heart disease and applications thereof. Background technique [0002] Coronary artery disease (CAD) is a complex cardiovascular disease (Cardiovascular disease, CVD) caused by genetic and environmental factors, the pathological basis of which is coronary atherosclerosis (Atherosclerosis, AS) or ( And) coronary artery spasm, when atherosclerosis occurs in the coronary arteries, it will cause narrowing or blockage of the coronary artery lumen, resulting in insufficient blood supply to the heart, so it is also called ischemic heart disease (IHD). CAD is one of the top ten killers endangering human health and one of the main causes of population death worldwide. Statistics from the World Health Organization (WHO) in 2016 show that globally, the death rate caused by IHD ranks first, causing huge economic and medical burdens on society and...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156C12Q2600/112Y02A50/30
Inventor 程翔查灵凤
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap