SNP (Single Nucleotide Polymorphism) sites related to coronary heart disease and application thereof

Abstract

The invention belongs to the field of biotechnology research, and discloses SNP (Single Nucleotide Polymorphism) sites related to coronary heart disease and application thereof. The invention specifically relates to application of an IL5 gene rs2069812 site or an IL5 gene rs2057687 site in preparation of drugs for examining and screening coronary heart diseases, wherein the coronary heart diseases comprise myocardial infarction and angina pectoris; the invention further discloses application of a detection reagent for the rs2069812 site of the IL5 gene and / or the rs2057687 site of the IL5 gene in preparation of drugs for examining and screening the coronary heart disease; the invention further discloses application of allelotype significantly associated with coronary heart disease susceptibility in preparation of drugs for coronary heart disease examination and screening; and the invention further discloses application of low-risk allele of the coronary heart disease in preparation of drugs for examining and screening the coronary heart disease. According to the site, a new coronary heart disease detection site is found, different risk levels are found for different alleles, and a new scheme is provided for subsequent diagnosis and prevention of coronary heart disease.

Description

technical field [0001] The invention belongs to the field of biotechnology research, and particularly relates to SNP sites related to coronary heart disease and applications thereof. Background technique [0002] Coronary artery disease (CAD) is a complex cardiovascular disease (Cardiovascular disease, CVD) caused by genetic and environmental factors, the pathological basis of which is coronary atherosclerosis (Atherosclerosis, AS) or ( And) coronary artery spasm, when atherosclerosis occurs in the coronary arteries, it will cause narrowing or blockage of the coronary artery lumen, resulting in insufficient blood supply to the heart, so it is also called ischemic heart disease (IHD). CAD is one of the top ten killers endangering human health and one of the main causes of population death worldwide. Statistics from the World Health Organization (WHO) in 2016 show that globally, the death rate caused by IHD ranks first, causing huge economic and medical burdens on society and...

AI Technical Summary

Problems solved by technology

[0004] Although a large number of susceptibility genes for coronary heart disease have been discovered through genetic research, these susceptibility genes can only explain about 28% of the heritability of coronary heart disease, and the heritability of coronary heart disease is as high as 40% through family clustering studies and twin studies. Therefore, there is still a considerable part of the genetic basis of coronary heart disease that has not been elucidated clearly. The genetic basis of coronary heart disease and the susceptibility genes of coronary heart disease still need further research

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