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Application of berbamine in preparation of medicine for treating Alzheimer's disease

A technology for Alzheimer's disease and berbamine, which is applied in the field of medicine, can solve the problems that berbamine has not been reported in Alzheimer's disease, and achieve shortening the time for new drug development, high safety, and good intestinal absorption Effect

Pending Publication Date: 2021-12-17
LIAONING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And berbamine hydrochloride, as a relatively mature preparation on the market, has been widely used clinically, but berbamine has not been reported for the treatment of Alzheimer's disease.

Method used

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  • Application of berbamine in preparation of medicine for treating Alzheimer's disease
  • Application of berbamine in preparation of medicine for treating Alzheimer's disease
  • Application of berbamine in preparation of medicine for treating Alzheimer's disease

Examples

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Embodiment Construction

[0046] In order to further clarify the present invention, a series of examples are given below, these examples are completely illustrative, they are only used to specifically describe the present invention, and should not be construed as limiting the present invention.

[0047] Application of Example Berbamine in the Preparation of Drugs for the Treatment of Alzheimer's Disease

[0048] Methods: Qualified mice were randomly divided into brain-localized injection of aluminum trichloride AD mouse model group, intraperitoneal injection of D-galactose and gavage of aluminum trichloride AD mouse model group, APP / PS1 double transgenic AD mouse model group group, control group, sham operation group (the sham operation group is to control the brain localization injection group, and only perform the same operation of scalp incision without localization injection) and the berbamine hydrochloride administration group. The administration group was given berbamine hydrochloride by gavage f...

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Abstract

The invention discloses an application of berbamine in preparation of a medicine for treating Alzheimer's disease. The invention specifically relates to an application of berbamine hydrochloride in treatment of Alzheimer's disease. It is indicated that the berbamine hydrochloride significantly improves the pathological characteristics of mice with the Alzheimer's disease, improves the learning and memory ability of the mice with the Alzheimer's disease, and has a certain treatment effect on the Alzheimer's disease.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of berbamine in the preparation of drugs for treating Alzheimer's disease. Background technique [0002] Alzheimer's Disease (AD) is the most common dementia in the world, affecting as many as 35 million people worldwide. Clinically, it is more common in the elderly, and the main feature is that patients show varying degrees of memory and cognitive decline. At present, the problem of population aging in my country is becoming more and more serious, and the occurrence of AD seriously threatens the physical and mental health of the elderly. Therefore, the prevention and treatment of AD has attracted the attention of the scientific community. Currently, only a limited number of drugs are clinically used to alleviate the development of AD. [0003] With the continuous deepening of research, the pathogenesis of AD is also gradually clarified, and the early theory...

Claims

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Application Information

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IPC IPC(8): A61K31/4748A61P25/28
CPCA61K31/4748A61P25/28
Inventor 陈长兰王海利钱峰吕晶
Owner LIAONING UNIVERSITY
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