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Method, device and storage medium for generating, updating and querying antibody database

A database and antibody technology, applied in the field of computational chemistry, can solve the problems of poor user experience of antibody database and incomplete antibody data, and achieve the effect of ensuring quality and improving quality.

Active Publication Date: 2022-06-17
北京晶泰科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Embodiments of the present invention provide a method, device, and storage medium for generating, updating, and querying an antibody database, so as to at least solve the technical problem that the antibody data in the existing antibody database is incomplete, resulting in poor user experience of the antibody database

Method used

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  • Method, device and storage medium for generating, updating and querying antibody database
  • Method, device and storage medium for generating, updating and querying antibody database
  • Method, device and storage medium for generating, updating and querying antibody database

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Embodiment 1

[0043] According to an embodiment of the present invention, an embodiment of a method for generating an antibody database is provided. It should be noted that the steps shown in the flowchart of the accompanying drawings may be executed in a computer system such as a set of computer-executable instructions, and, Although a logical order is shown in the flowchart, in some cases steps shown or described may be performed in an order different from that herein.

[0044] In addition, it should be noted that a terminal device can be used as the execution subject of the method provided in this embodiment, and the terminal device can construct and manage the antibody database, so as to realize real-time update of the antibody database, data cleaning and repair of the antibody structure, Wherein, the terminal device has at least an input unit, an output unit and a processing unit, the input unit is used for acquiring relevant data required for constructing and / or updating the antibody d...

Embodiment 2

[0113] According to an embodiment of the present invention, an embodiment of a method for updating an antibody database is also provided, wherein, image 3 is a flow chart of an update method for an antibody database according to an embodiment of the present invention, such as image 3 As shown, the method includes the following steps:

[0114] Step S302, acquiring structural information of the newly added antibody and sequence information of the newly added antibody.

[0115] In step S302, the terminal device may obtain the structure file and sequence file of the newly added antibody from the protein structure database, and obtain the structure information and sequence information respectively from the structure file and the sequence file, wherein the structure file at least includes the structure file of the newly added antibody. Antibody structure information. The sequence file includes at least the sequence information of the amino acids that make up the newly added antib...

Embodiment 3

[0130] According to an embodiment of the present invention, an embodiment of a data query method is also provided, wherein, Figure 4 is a flowchart of a data query method according to an embodiment of the present invention, such as Figure 4 As shown, the method includes the following steps:

[0131] In step S402, key information of the antibody to be queried is acquired.

[0132] Optionally, the user can perform data retrieval of the key information of the antibody to be queried by using an interfaced database query tool module. Wherein, the input data (that is, the above-mentioned key information) of the database query tool module can be, but not limited to, the structure number (such as PDB number) of the antibody to be queried, the antibody type, the antibody heavy chain or light chain sequence to be compared, etc. Wait.

[0133] Step S404, according to the key information, the antibody data corresponding to the key information is obtained by querying the antibody data...

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Abstract

The invention discloses a method, device and storage medium for generating, updating and querying an antibody database. Among them, the generation method of the antibody database includes: obtaining the structural information and sequence information of the original antibody; analyzing the sequence information of the original antibody, and numbering the antibody sequence in the sequence information; Data cleaning and structure optimization to obtain the optimized structure information of the target antibody; generate an antibody database based on the structure information of the target antibody. The invention solves the technical problem that the antibody data in the existing antibody database is incomplete, which leads to poor user experience of the antibody database.

Description

technical field [0001] The present invention relates to the technical field of computational chemistry, in particular, to a method, device and storage medium for generating, updating and querying an antibody database. Background technique [0002] A database is a warehouse that organizes, stores and manages data according to a data structure. It is a collection of large amounts of data stored in a computer for a long time, organized, sharable, and managed uniformly. In the field of chemistry, several public databases have been established to store antibody data. [0003] In practical applications, it is found that the quality of antibody data stored in existing antibody databases is uneven, and even some antibody structural data are incomplete, which seriously affects the use of antibody databases. Moreover, existing antibody databases are often not updated in real time, resulting in slow database updates. [0004] For the above problems, no effective solution has been pro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G06F16/2458G06F16/23G06F16/215
CPCG06F16/2474G06F16/215G06F16/23
Inventor 王天元吴炜坤黄健
Owner 北京晶泰科技有限公司
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