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Method for rapidly detecting adulterated lonicerae flos in heat-clearing and detoxifying oral liquid

A heat-clearing, detoxifying, and rapid inspection technology, applied to measuring devices, instruments, scientific instruments, etc., can solve problems such as failure to effectively supervise behaviors, and achieve the effect of improving the level of quality control

Pending Publication Date: 2022-03-04
苏州市药品检验检测研究中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The standard of Qingrejiedu Oral Liquid does not involve the inspection of the mountain silver flower, and it fails to effectively supervise the behavior of adding the mountain silver flower to the production.

Method used

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  • Method for rapidly detecting adulterated lonicerae flos in heat-clearing and detoxifying oral liquid
  • Method for rapidly detecting adulterated lonicerae flos in heat-clearing and detoxifying oral liquid
  • Method for rapidly detecting adulterated lonicerae flos in heat-clearing and detoxifying oral liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Inspection method of Qingrejiedu Oral Liquid Zhongyinhua

[0017] [Inspection] Determination of Shanyinhua according to high performance liquid chromatography (general rule 0512 of "Chinese Pharmacopoeia" 2020 edition).

[0018] Chromatographic conditions and system suitability test: Octadecylsilane bonded silica gel is used as filler; acetonitrile is used as mobile phase A, 0.4% acetic acid solution is used as mobile phase B, gradient elution is carried out according to the regulations in the table below, and the flow rate is 1ml per minute; detection by evaporative light scattering detector, splitless injection, column temperature: 30°C. The number of theoretical plates should not be less than 5000 based on the calculation of Lonicera saponin B.

[0019]

[0020] Preparation of Reference Substance Solution: Take an appropriate amount of Lonicera saponin B reference substance, accurately weigh it, add 50% methanol to make a reference solution containing ...

Embodiment 2

[0031] Example 2: Construction of inspection method

[0032] 1. Standard process method

[0033] Operate according to the preparation method in the quality standard of "Qingrejiedu Oral Liquid" recorded in the 2020 edition of "Chinese Pharmacopoeia".

[0034] Prescription: gypsum 670g, honeysuckle 134g, scrophulariaceae 107g, rehmannia glutinosa 80g, forsythia 67g, gardenia 67g, sweet ditin 67g, scutellaria baicalensis 67g, gentian 67g, isatidis 67g, anemarrhena 54g, radix radix 54g.

[0035] Preparation method: the above twelve flavors, except honeysuckle and scutellaria, the other 10 flavors such as gypsum are first soaked in water for 1 hour, decocted (after boiling, then add honeysuckle and scutellaria baicalensis) twice, the first time for 1 hour, the second time After 40 minutes, filter, combine the filtrate, concentrate the filtrate to a relative density of about 1.17 (80°C), add ethanol to make the alcohol content reach 65% to 70%, refrigerate for 48 hours, filter, re...

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Abstract

The invention discloses a method for rapidly detecting adulterated lonicerae flos in oral liquid capable of clearing away heat and toxic materials, which comprises the following steps of: detecting whether macranthoidin B exists in the oral liquid capable of clearing away heat and toxic materials or not by high performance liquid chromatography or high performance liquid chromatography-mass spectrometry, if the macranthoidin B is detected, indicating that the adulterated lonicerae flos is adulterated; if the macranthoidin B is not detected, it shows that the pseudo lonicerae flos is not doped. According to the method provided by the invention, the violation problem of adulteration of the lonicerae flos in the heat-clearing and detoxifying oral liquid can be effectively checked, the behavior of adulteration of the lonicerae flos in production can be effectively supervised, and the quality control level of the heat-clearing and detoxifying oral liquid can be effectively improved.

Description

technical field [0001] The invention belongs to the field of drug analysis, relates to the quality control of traditional Chinese medicines, in particular to a method for quickly checking the adulterated mountain silver flower in Qingrejiedu oral liquid. Background technique [0002] At present, many preparations containing honeysuckle medicinal materials in the 2020 edition of the "Chinese Pharmacopoeia" have been inspected for the active ingredient Lonicera cinerea in Lonicerae japonicus, and the standard stipulates that the main component Lonicera cinerea can not be detected. The standard of Qingrejiedu Oral Liquid does not involve the inspection of Linicum japonicus, and it fails to effectively supervise the behavior of adulterating Linic japonicus in production. [0003] In order to solve the above problems, the present invention is proposed. Contents of the invention [0004] The invention aims to overcome the deficiencies of the prior art, and provides a method for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/72
CPCG01N30/02G01N30/72G01N2030/027
Inventor 钱叶飞王亚琼朱梦张超陈卫薛满
Owner 苏州市药品检验检测研究中心
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