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Pharmaceutical composition for treating locally advanced microsatellite stable colorectal cancer and application thereof

A technology for microsatellite stabilization and colorectal cancer, applied in the field of medicine, can solve the problem of no clear standard treatment for colorectal cancer, and achieve safe and effective treatment effects

Active Publication Date: 2022-05-24
THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Currently there is no clear standard regimen for the treatment of locally advanced (T4NxM0) microsatellite stable (MSS) colorectal cancer

Method used

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  • Pharmaceutical composition for treating locally advanced microsatellite stable colorectal cancer and application thereof

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Embodiment 1

[0023] 1. Subject selection criteria:

[0024] 1) Histologically confirmed colorectal adenocarcinoma (colon, upper rectum);

[0025] 2) Tumor biopsy immunohistochemistry showed pMMR, that is, MSH1, MSH2, MSH6, and PMS2 were all expressed and determined to be microsatellite stability (MSS); MRI examination confirmed that the lower border of the tumor was above peritoneal reflection;

[0026] 3) Clinical stage T4NxM0, with or without positive MRF, with or without positive EMVI;

[0027] 4) Preoperative staging method: All patients were preoperatively staging with enhanced CT. Periintestinal metastatic lymph nodes: short diameter ≥ 10 mm lymph nodes or lymph node shape and CT features consistent with typical lymph node metastasis; preoperative chest, abdomen CT, pelvic MRI ruled out Distant metastasis;

[0028] 5) There is no sign of intestinal obstruction; or the intestinal obstruction has been relieved after proximal colostomy;

[0029] 6) No previous colorectal surgery; no ...

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Abstract

The invention relates to the technical field of medicines, and particularly discloses a medicine composition for treating locally advanced microsatellite stable colorectal cancer and application. The pharmaceutical composition disclosed by the invention comprises mFOLFOX6, bevacizumab and a PD-1 (programmed death-1) inhibitor. Experiments prove that the pharmaceutical composition is used for treating MSS CRC of local advanced stage (T4NxM0), 14 cases achieve main pathological remission (tumor recession exceeds 90%), 10 cases have complete pathological remission (no tumor cell residue), tumor markers are all reduced to be normal, no lethal SAE event exists, and the pharmaceutical composition has good safety and effectiveness. Therefore, aiming at a patient suffering from the locally advanced (T4NxM0) microsatellite stable colorectal cancer, the medicine composition is combined to shrink the tumor as much as possible, so that the R0 excision rate and the PCR rate (complete pathologic remission rate) are improved as much as possible, and the toxic and side effects of three-medicine chemotherapy and synchronous chemoradiotherapy are avoided.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a pharmaceutical composition and application for treating locally advanced (T4NxM0) microsatellite stable (pMMR / MSS) colorectal cancer. Background technique [0002] Colorectal cancer (CRC) is one of the most common malignant tumors in humans. At present, radical resection-preoperative neoadjuvant chemotherapy for colorectal cancer is still the standard comprehensive treatment mode recommended by the two major international guidelines of NCCN and ESMO, as well as the Chinese CSCO guidelines. Mismatch repair protein (MMR) expression and microsatellite stability are important factors affecting the efficacy of immunotherapy. In the past two or three years, PD-1 monoclonal antibody immunotherapy has shown remarkable curative effect in the second-line / first-line treatment of dMMR / MSI-H advanced colorectal cancer and neoadjuvant treatment of early colon cancer. Toxicity is controll...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61P35/00A61K31/513A61K31/555A61K31/7068
CPCA61K31/555A61K31/513A61K31/7068A61K39/3955A61K9/0019A61P35/00A61K2039/507A61K2300/00A61K31/4188A61K31/519A61K31/704A61K31/337
Inventor 黄俊黄美近邓艳红裴风云汪建平
Owner THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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