Pluripotent stem cell for expressing LAG-3 targeting inhibition factor, and derivative and application of pluripotent stem cell
A technology of pluripotent stem cells and LAG-3, which is applied in the field of pluripotent stem cells and their derivatives and applications, can solve problems such as cytokine storm and tissue necrosis, and achieve the effect of eliminating tumor cells, inhibiting expression, and improving immune compatibility
Pending Publication Date: 2022-06-24
FUTURE HOMO SAPIENS INST OF REGENERATIVE MEDICINE CO LTD (FHSR) +1
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[0009] In addition, some people have designed to induce killing of donor tissues and cells after they become diseased by inducing suicide genes. The loss of suitable donor cells, tissues and organs after killing is another big problem
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[0113] In order to make the invention purpose, technical solutions and technical effects of the present invention clearer, the present invention will be further described in detail below with reference to the specific embodiments. It should be understood that the specific embodiments described in this specification are only for explaining the present invention, rather than for limiting the present invention.
[0114] The experimental materials and reagents used, unless otherwise specified, are conventional consumables and reagents that can be obtained from commercial sources.
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The invention discloses a pluripotent stem cell for expressing an LAG-3 targeting inhibition factor as well as a derivative and application of the pluripotent stem cell. An expression sequence of an LAG-3 inhibitory factor is introduced into a genome of the pluripotent stem cell or the derivative thereof, and the LAG-3 inhibitory factor is at least one of shRNA (short hairpin ribonucleic acid) and / or shRNA-miR (short hairpin ribonucleic acid-miR) targeting LAG-3. After the LAG-3 inhibitory factor expressed by the pluripotent stem cell or the derivative thereof is wrapped by the exosome, the exosome carries the LAG-3 inhibitory factor to be combined with a target cell and release the LAG-3 inhibitory factor contained in the target cell, so that the expression of the LAG-3 is inhibited, the immunosuppression is relieved, the immune system is activated, and tumor cells are effectively removed.
Description
technical field [0001] The invention belongs to the technical field of genetic engineering, and in particular relates to a pluripotent stem cell expressing a LAG-3 targeting inhibitory factor, a derivative thereof and an application thereof. Background technique [0002] Stem cells are a type of "seed" cells that have the ability to self-renew and differentiate into specific functional somatic cells. They have the potential to regenerate into various tissues and organs and the human body. They play a role in major biological activities such as immune response, aging, and tumorigenesis. core and irreplaceable role. According to the degree of stem cell characteristics, stem cells are mainly divided into: totipotent stem cells (Totipotent stem cells), pluripotent stem cells (PSCs) and adult stem cells (adult stem cells). Among them, pluripotent stem cells (PSCs) have almost unlimited self-renewal ability and the potential to develop and differentiate into organs, tissues and c...
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Login to View More IPC IPC(8): C12N5/10C12N15/113C12N15/85A61K35/545A61K35/54A61K35/28A61K35/30A61P35/00
CPCC07K14/70539C07K14/4705C07K14/70503C12N15/1138C12N15/85C12N5/0606C12N5/0608C12N5/0603C12N5/0693C12N5/0696C12N5/0662C12N5/0623A61K35/545A61K35/54A61K35/28A61K35/30A61P35/00C12N2510/00C12N2310/14C12N2830/006
Inventor 王淋立陈月花杨建国莫健
Owner FUTURE HOMO SAPIENS INST OF REGENERATIVE MEDICINE CO LTD (FHSR)
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