Application of construction of liver cancer identification tool based on specific lectin combination and alpha fetoprotein

A lectin and liver cancer technology, applied in the field of biomedical detection, can solve problems such as poor sensitivity and specificity, and limited diagnostic value

Pending Publication Date: 2022-07-12
SHENGJING HOSPITAL OF CHINA MEDICAL UNIV
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Problems solved by technology

So far, alpha-fetoprotein (a-fetoprotein, AFP) is still an important tumor marker for clinical diagnosis of primary liver cancer, but its diagnostic value is limited due to its poor sensitivity and specificity

Method used

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  • Application of construction of liver cancer identification tool based on specific lectin combination and alpha fetoprotein
  • Application of construction of liver cancer identification tool based on specific lectin combination and alpha fetoprotein
  • Application of construction of liver cancer identification tool based on specific lectin combination and alpha fetoprotein

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Embodiment 1

[0054] 1. Research methods.

[0055] 1.1. Group the training group and the validation group.

[0056] A total of 207 serum samples were collected from Shengjing Hospital Affiliated to China Medical University from 2019 to 2020, including 97 HCC patients, 50 HBC patients, 30 CHB patients and 30 healthy control patients.

[0057] 207 samples were randomized into stratified groups. When drawing up the randomization plan, consider grouping the subjects first by disease; then by sex within each disease; and then by age among men and women, there will be 16 subgroups. In these 16 subgroups, the subjects were randomly divided into training group and validation group according to 2:1 (random seed number 20201115). A total of 207 samples were randomly divided into a training group (138 cases in total, including 65 HCC, 20 CHB, 33 HBC, and 20 healthy controls) and a validation group (a total of 69 cases, including 32 HCC and 10 CHB cases). , 17 cases of HBC and 10 cases of healthy co...

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Abstract

The invention belongs to the field of biomedical detection, and relates to application of a specific lectin combination combined with IgG and/or IgM in serum and alpha fetoprotein (AFP) to construction of a test tool for identifying liver cancer. By utilizing a lectin chip technology, lectin which is combined with IgG (12 types)/IgM (11 types) is screened out, and differences exist between liver cancer and healthy people, and hepatitis B and hepatitis B cirrhosis patients. A test tool for identifying the liver cancer is jointly constructed based on a specific lectin combination combined with IgG/IgM in serum and AFP, a liver cancer identification combined diagnosis model is established in combination with an algorithm, the test tool can identify and diagnose the liver cancer and distinguish the liver cancer from hepatitis B cirrhosis and chronic hepatitis B diseases, and meanwhile, for AFP negative patients, the test tool can be used for identifying and diagnosing the liver cancer. The method can be used as a powerful supplement for in-vitro diagnosis.

Description

technical field [0001] The invention belongs to the field of biomedical detection, and relates to the application of constructing a liver cancer identification tool based on a specific lectin combination and alpha-fetoprotein, in particular to a specific lectin combination combined with IgG and / or IgM in serum and alpha-fetoprotein (AFP) Application of a test tool to identify liver cancer. Background technique [0002] Primary liver cancer is one of the most common malignant tumors in clinic. According to cell type, it can be divided into hepatocellular carcinoma (HCC), cholangiocarcinoma and mixed liver cancer. Among them, hepatocellular carcinoma is the main type, about 90%. According to statistics, there are about 780,000 new cases worldwide, ranking sixth among malignant tumors; about 750,000 deaths, ranking second among malignant tumors. In my country, there are about 390,000 new cases of liver cancer and 380,000 deaths, ranking fifth in incidence and second in death....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574G01N33/68G16H50/20
CPCG01N33/57476G01N33/57438G01N33/6854G16H50/20G01N2333/4724
Inventor 秦晓松刘建华张司华
Owner SHENGJING HOSPITAL OF CHINA MEDICAL UNIV
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