38results about How to "Improve diagnostic sensitivity" patented technology

The invention discloses a turbine generator rotor interturn short-circuit fault diagnosis method based on the end distortion effect. The method includes the steps of firstly, installing a magnetic field detection coil on an end distortion magnetic flux path of a turbine generator; secondly, online collecting voltage signals sensed by the magnetic field detecting coil through a data collecting instrument, conducting fast fourier transformation on the signals, and obtaining a spectrogram of the signals; thirdly, diagnosing whether the interturn short-circuit fault exists in rotor windings of the turbine generator or not according to the amplitude changing situation of all spectrum components of the signals. The interturn short-circuit fault in the rotor windings of the turbine generator is diagnosed according to the amplitude changing situation of some characteristic frequency components in the voltage signals sensed by the magnetic field detecting coil, and the turbine generator rotor interturn short-circuit fault diagnosis method has the advantages that diagnosing flexibility is high and sensors are convenient to install, is universally suitable for various types of turbine generators in an electric system, and has wide application prospects.

The invention belongs to the field of biological sample detection and discloses an application of a non-small cell lung cancer pleural effusion tumor marker. SP70 is used as the non-small cell lung cancer pleural effusion tumor marker to be applied to preparation of non-small cell lung cancer pleural effusion and/or pleural effusion cast-off cell diagnostic reagents. A monoclonal antibody of the SP70 is applied to preparation of the non-small cell lung cancer pleural effusion and/or pleural effusion cast-off cell diagnostic reagents. A direct immunofluorescence detection kit of non-small cell lung cancer pleural effusion cast-off cells contains the fluorescently-labeled monoclonal antibody of the SP70, 5% of bovine serum albumin (BSA) and 1% of a phosphate buffer solution (PBS). According to a great quantity of experimental researches, SP70 antigens can serve as a sensitive and specific detection index of malignancy pleural effusion caused by non-small cell lung cancers, simultaneously, the SP70 antigens in the pleural effusion and the pleural effusion cast-off cells can be detected, and sensitivity and specificity of carcinogenic pleural effusion diagnosis can be greatly improved.

The invention discloses a positioning automatic discrimination system of acute myocardial infarction based on CNN neural network, and relates to the technical field of myocardial infarction positioning discrimination. The positioning automatic discrimination system comprises a data acquisition system, a cloud platform data storage system, a positioning discrimination analysis system and a data display system. A wearable ECG monitor is connected with to-be-discriminated personnel to record and generate a 12 lead primitive electrocardiogram; an electrocardiogram acquisition system acquires 12 lead primitive electrocardiogram data including wave amplitude of P wave, wave amplitude of a QRS wave group, wave amplitude of a ST section and wave amplitude of T wave; and the positioning discrimination analysis system utilizes a positioning discrimination model acquired based on CNN neural network training to carry out convolution calculation to acquire discrimination intermediate data, and thediscrimination intermediate data are mapped by a sigmoid function to acquire discrimination result data, so that positioning discrimination of occurrence positions of the acute myocardial infarction of the to-be-discriminated personnel is made. The positioning automatic discrimination system of the acute myocardial infarction based on the CNN neural network makes accurate positioning discrimination of the occurrence positions of the acute myocardial infarction of the to-be-discriminated personnel.

The invention relates to a method and a system for constructing a disease risk prediction model based on sequencing and machine learning. The system is embedded with a disease risk prediction model developed by utilizing machine learning, and the disease risk of a subject is judged according to the risk prediction model by receiving sequencing information from the subject.

The invention discloses lung cancer targeted radioactive nano-particles and a preparation method thereof. The nano-particles comprise iron oxide nano-particles of which the particle size is smaller than or equal to 10 nm, polyacrylic acid, propargyl amine compounds (as shown in specifications ), cyclic peptide (as shown in specifications) containing the sequence of arginine-glycine-aspartic acid-phenylalanine-lysine-azidoacetic acid, small peptide (as shown in specifications) containing the sequence of tyrosine-histidine-tryptophan-tyrosine-glycine-tyrosine-threonine-proline-glutamine-asparaginate-valine-isoleucine-lysine-azidoacetic acid and radioactive nuclides containing fluorine-18(18F). The prepared nano-particles can be used for performing PET/MRI early-stage and specific diagnosis on the lung tumor.

The invention discloses a qualitative automatic discrimination system of acute myocardial infarction based on CNN neural network, and relates to the technical field of myocardial infarction qualitative discrimination. The qualitative automatic discrimination system comprises a data acquisition system, a cloud platform data storage system, a qualitative discrimination analysis system and a data display system. A wearable ECG monitor is connected with to-be-discriminated personnel to record and generate a 12 lead primitive electrocardiogram; an electrocardiogram acquisition system acquires 12 lead primitive electrocardiogram data including wave amplitude of P wave, wave amplitude of a QRS wave group, wave amplitude of a ST section and wave amplitude of T wave; and the qualitative discrimination analysis system utilizes a qualitative discrimination model acquired based on CNN neural network training to carry out convolution calculation to acquire discrimination intermediate data, and thediscrimination intermediate data are mapped by a sigmoid function to acquire discrimination result data, so that qualitative discrimination of whether the to-be-discriminated personnel suffering fromthe acute myocardial infarction or not is made. The qualitative automatic discrimination system of the acute myocardial infarction based on the CNN neural network makes accurate qualitative discrimination of whether the to-be-discriminated personnel suffering from the acute myocardial infarction or not.

The invention relates to the field of molecular biology, and in particular relates to a metabonomics marker kit for self-assembly post-operation delirium and application of the metabonomics marker kit. The kit for predicting post-operation delirium contains various metabonomics-related molecules, can rapidly detect the metabolite level of elderly patients, effectively distinguishes the metabolitelevels and predicts postoperative delirium. Meanwhile, the kit is successfully applied to detection of metabolites in serum of a post-operation delirium patient, and the detection result shows that the level difference of ten metabolites in serum of the post-operation delirium patient (n = 15) and serum of a post-operation non-delirium patient (n = 41) has statistical significance (P is less than0.05).

The invention discloses a fluid control device and method for enriching and coloring cells. The device comprises a filtering cavity body, a rotary disc, a sample chamber, liquid pre-loading chambers and a waste liquid chamber, the filtering cavity body is detachably arranged on the rotary disc, the sample chamber and the plurality of liquid pre-loading chambers are uniformly arranged in the circumferential direction of the filtering cavity body, the waste liquid chamber is arranged at the bottom of the rotary disc. The method generates pressure difference by pushing and pulling the piston, rotates the filtering cavity to form a channel to flow fluid into the filtering cavity and carry out filtering, and enriches the filtered cells on the microporous filter membrane and colors the cells onthe microporous filter membrane. The invention quantitatively adds liquid in the coloring process, reduces the randomness, improves the repeatability, and can avoid the risk caused by the repeated contact of operators with samples. The invention relates to the technical field of medical sample processing.

The invention discloses a specific primer pair, reagent and kit for detecting a gene C4BPA mRNA in human peripheral blood leukocytes, and applications of the specific primer pair, reagent and kit. A nucleotide sequence of an upstream primer of the primer pair for detection is shown as SEQ ID No. 1, and the nucleotide sequence of a downstream primer is shown as SEQ ID No. 2. Clinically, through the detection of C4BPA mRNA in the human peripheral blood leukocytes, clopidogrel resistance can be predicted, so that a novel detection method can be provided for judging the clinical effects and prognosis of clopidogrel and guiding clinical rational use of drugs.

The invention belongs to the field of biomedical detection, and relates to application of a specific lectin combination combined with IgG and/or IgM in serum and alpha fetoprotein (AFP) to construction of a test tool for identifying liver cancer. By utilizing a lectin chip technology, lectin which is combined with IgG (12 types)/IgM (11 types) is screened out, and differences exist between liver cancer and healthy people, and hepatitis B and hepatitis B cirrhosis patients. A test tool for identifying the liver cancer is jointly constructed based on a specific lectin combination combined with IgG/IgM in serum and AFP, a liver cancer identification combined diagnosis model is established in combination with an algorithm, the test tool can identify and diagnose the liver cancer and distinguish the liver cancer from hepatitis B cirrhosis and chronic hepatitis B diseases, and meanwhile, for AFP negative patients, the test tool can be used for identifying and diagnosing the liver cancer. The method can be used as a powerful supplement for in-vitro diagnosis.

The invention relates to a recombinant mixed humulus pollen allergen vaccine and a preparation method thereof, which are used for effectively diagnosing and performing specific immunotherapy on allergic diseases induced by humulus pollen. The recombinant vaccine of the invention covers 15 kinds of humulus pollen allergen proteins, can effectively diagnose allergic diseases induced by humulus pollen and perform specific immunotherapy on them.

An embodiment of the present invention provides a composition for diagnosing hemorrhagic fever with renal syndrome, comprising: a recombinant protein comprising a Seoul virus- and Puumala virus- derived nucleocapsid protein; and a Hantaan virus-derived recombinant glycoprotein.

The invention relates to application of spliceosome-associated protein 130 (SAP130) in diagnosis of idiopathic pulmonary interstitial fibrosis and assessment of disease severity. Clinical case research finds that the spliceosome-associated protein 130 can be used for diagnosing idiopathic pulmonary interstitial fibrosis and can be used for evaluating the severity of diseases. According to the method, peripheral blood of a patient is directly extracted for SAP130 detection, and the ELISA method is adopted, so that the detection is simple and convenient, and the detection time is short. The diagnosis efficiency and the diagnosis sensitivity are high. The invention provides a new means for diagnosis and disease assessment of idiopathic pulmonary fibrosis.