Application of splicing-associated protein 130 in diagnosis of idiopathic pulmonary interstitial fibrosis and assessment of disease severity

A technology related to protein and pulmonary fibrosis, applied in the field of biomedicine

Active Publication Date: 2021-10-19
RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] However, there is no report on the expression of SAP130 in IPF disease

Method used

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  • Application of splicing-associated protein 130 in diagnosis of idiopathic pulmonary interstitial fibrosis and assessment of disease severity
  • Application of splicing-associated protein 130 in diagnosis of idiopathic pulmonary interstitial fibrosis and assessment of disease severity
  • Application of splicing-associated protein 130 in diagnosis of idiopathic pulmonary interstitial fibrosis and assessment of disease severity

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Embodiment 1

[0022] 1. Method

[0023] In order to study the clinical correlation between SAP130 and IPF, the SAP130 levels of 83 IPF patients and 38 healthy controls were detected and compared by ELISA method. Human serum samples and lung tissue sections of IPF patients and controls were obtained from Ruijin Hospital. All experiments were approved by the hospital ethics committee. The enrollment period is from January 2017 to December 2019. The lung tissue wax blocks used for immunohistochemistry and immunofluorescence were surgically removed original lung organs from IPF patients who received lung transplantation. The lung tissue of the control group came from a patient who underwent surgery for pulmonary nodules in a hospital, and the postoperative pathological diagnosis was benign nodules. The lung tissue used was as far away from the lesion as possible. The serum of IPF patients came from six domestic hospitals. Peripheral blood serum detection SAP130 healthy control group was ma...

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Abstract

The invention relates to application of spliceosome-associated protein 130 (SAP130) in diagnosis of idiopathic pulmonary interstitial fibrosis and assessment of disease severity. Clinical case research finds that the spliceosome-associated protein 130 can be used for diagnosing idiopathic pulmonary interstitial fibrosis and can be used for evaluating the severity of diseases. According to the method, peripheral blood of a patient is directly extracted for SAP130 detection, and the ELISA method is adopted, so that the detection is simple and convenient, and the detection time is short. The diagnosis efficiency and the diagnosis sensitivity are high. The invention provides a new means for diagnosis and disease assessment of idiopathic pulmonary fibrosis.

Description

technical field [0001] The present invention relates to the field of biomedicine, in particular to the application of splice body-associated protein 130 in the diagnosis of idiopathic pulmonary interstitial fibrosis and the assessment of disease severity. Background technique [0002] Idiopathic pulmonary fibrosis (IPF) is a common pulmonary interstitial disease, characterized by pulmonary fibrosis, with a prevalence of about (2-29) / 100,000 and a median survival time of only about 3 years. IPF is more common in men, and the prevalence increases significantly with age. The mortality rate of IPF patients worldwide is on the rise. The main symptoms of IPF are progressive dyspnea, eventually leading to respiratory failure or death, and the pathological features are mainly abnormal extracellular matrix deposition and abnormal structural remodeling of lung tissue. At present, more and more studies believe that pulmonary fibrosis is the result of persistent lung injury and abnorm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68G01N33/53
CPCG01N33/6893G01N33/53G01N2800/12G01N2800/50G01N2333/4706
Inventor 瞿介明刘凯雄
Owner RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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