EGFR receptor-targeted tumor diagnosis and treatment radioactive nanoparticles and preparation method thereof
A nanoparticle and radioactive technology, applied in the field of novel nanoparticles and their preparation, can solve problems such as the inability to achieve combined therapy
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0067] The preparation method of radioactive nanoparticles for tumor diagnosis and treatment targeting tumor EGFR receptors of the present invention:
[0068] Take 8mmol PAA and 4mmol FeCl 3 Dissolve in diethylene glycol DEG (30mL), then transfer the above mixture into a 50mL three-necked flask, and place it in a microwave oven with vigorous stirring. When the temperature reached 220° C., 2 mL of NaOH solution (100 mg / mL, 80° C.) prepared in DEG was quickly added thereto. Further heating and mixing with a microwave heating power of 800W for 10 min, and cooling to room temperature of 20° C. to obtain a black colloid of iron oxide. The final product was obtained after centrifugation and washing.
[0069] Take 16.9mg AgNO 3 Dissolve in 1mL water, 15mg cisplatin is dissolved in 1mL water, AgNO 3 The solution was added dropwise to cisplatin, heated at 50°C for 1 h, and then centrifuged at 6000 r / min for 5 min to separate AgCl.
[0070] Take 1.5 mg of iron oxide nanoparticle su...
Embodiment 2
[0076] A tumor EGFR receptor-targeted radioactive nanoparticle is prepared by the following method:
[0077] (1) carrier preparation
[0078] Use ferric chloride, polyacrylic acid (PAA) and diethylene glycol (DEG), quickly add NaOH solution dissolved in DEG at 180 ° C, react for 15 minutes, and prepare iron oxide nanoparticles after cooling, in which ferric chloride and PAA The molar ratio of ferric chloride is 1:1, and the mass volume ratio of ferric chloride and DEG is 1:45mol / L;
[0079] (2) Cisplatin loading
[0080] The loading method of cisplatin is as follows: silver nitrate and cisplatin are mixed at a molar ratio of 1:1, react at 40°C to obtain cisplatin hydrate, then add cisplatin hydrate to the iron oxide nanoparticles prepared above for reaction, cisplatin hydrate Platinum and iron oxide nanoparticles were mixed at a mass ratio of 3:3, and stirred and reacted for 2 hours by magnetic stirring to obtain cisplatin-supported iron oxide nanoparticles;
[0081] (3) Do...
Embodiment 3
[0090] A tumor EGFR receptor-targeted radioactive nanoparticle is prepared by the following method:
[0091] (1) carrier preparation
[0092] Use ferric chloride, polyacrylic acid (PAA) and diethylene glycol (DEG), quickly add NaOH solution dissolved in DEG at 240 ° C, react for 5 minutes, and prepare iron oxide nanoparticles after cooling, in which ferric chloride and PAA The molar ratio of ferric chloride is 1:3, and the mass volume ratio of ferric chloride and DEG is 1:55mol / L;
[0093] (2) Cisplatin loading
[0094] The loading method of cisplatin is as follows: silver nitrate and cisplatin are mixed at a molar ratio of 5:1, react at 60°C to obtain cisplatin hydrate, then add cisplatin hydrate to the iron oxide nanoparticles prepared above for reaction, cisplatin hydrate Platinum and iron oxide nanoparticles were mixed at a mass ratio of 3:6, and stirred and reacted by magnetic stirring for 0.5h to obtain cisplatin-supported iron oxide nanoparticles;
[0095] (3) Dopami...
PUM
Property | Measurement | Unit |
---|---|---|
diameter | aaaaa | aaaaa |
molecular weight | aaaaa | aaaaa |
diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com