Use of levobutylphthalide in prevention and cure of dementia

A technology of n-butylphthalide and dementia, applied in medical preparations containing active ingredients, active ingredients of heterocyclic compounds, organic active ingredients, etc., can solve problems that have not yet been seen

Inactive Publication Date: 2005-01-19
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since then, it has been reported that celery extract has an improving effect on learning and memory of middle-aged and elderly mice (Li Jing et al. The influence of celery extract on learning and memory of middle-aged and elderly mice Chinese Herbal Medicine 1996, 27 (2): 104-105; Liu Luosheng et al.: An Quality Standard Research of Qingyizhi Capsules Shandong Medical University Journal 2001, 39 (6): 562-564), but so far there is no optical stereoisomer - L-n-butylphthalide (L-NBP) for the treatment of senile reports of dementia

Method used

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  • Use of levobutylphthalide in prevention and cure of dementia
  • Use of levobutylphthalide in prevention and cure of dementia
  • Use of levobutylphthalide in prevention and cure of dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] 1. Example 1 The therapeutic effect of L-n-butylphthalide on one of senile dementia, vascular dementia

[0048] Materials and methods

[0049] Reagents and Medicines

[0050] L-, D-, DL-NBP were provided by the synthesis laboratory of our institute, the optical and chemical purity were >98%, and the optical rotations were -66.49, +66.88 and 0 degrees in turn. Formulated with vegetable oil.

[0051] instrument

[0052] Morris water maze automatic monitor, avoiding the obscura was developed by the Instrument and Electricity Department of the Institute of Materia Medica, Chinese Academy of Medical Sciences

[0053] 2-VO model establishment

[0054] Male Wistar rats, 10 weeks old, with a weight of about 280 grams, were placed in a cage for every 5 rats, and the room temperature was kept at 23°C, with free access to food and water. Rats were anesthetized with sodium pentobarbital (40 mg / kg), the bilateral common carotid arteries were exposed, and the capsule of the comm...

Embodiment 2

[0085] Example 2 L-n-butylphthalide can significantly improve the beta-amyloid peptide (1-40) caused

[0086] Alzheimer's Symptoms

[0087] Materials and methods

[0088] Reagents and medicines: L-NBP is provided by the synthesis laboratory of our institute and prepared with vegetable oil. Aβ(1-40) was purchased from Sigma. The Alzet brain micro-osmotic pump perfusion device was purchased from Durect Company of the United States. Instrument: Morris water maze automatic monitoring instrument and experimental methods, see the above experiments on learning and memory impairment in rats with cerebral hypoperfusion

[0089] Model establishment: Male Wistar rats, 10 weeks old, weighing about 280 grams, placed one animal in each cage, kept the room temperature at 23°C, and had free access to food and water. Rats were anesthetized with pentobarbital sodium (40 mg / kg), fixed on a stereotaxic apparatus in the abdominal position, cut the skin of the head, and implanted a cannula for ...

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Abstract

The invention discloses the use of levogyration n-butyl benzene phthaleins in preparing medicament for preventing and treating aphrenia, in particular Hammer disease and blood vessel aphrenia.

Description

technical field [0001] The invention relates to the use of L-n-butylphthalide and the composition containing L-n-butylphthalide for treating dementia. Background technique [0002] Senile dementia or Alzheimer's disease (Alzheimer's disease, AD) is a progressive degenerative neurological disease characterized by clinical and pathological features. Its clinical manifestations are mainly memory (especially near memory) loss, low cognitive ability, slow thinking, spatial orientation disorder and so on. The pathological manifestations are β-amyloid peptide (Aβ) combined with other molecules, neurons and non-neural cells to form senile plaques and the formation of intracellular neurofibrillary tangles (neurofibrillary tangles, NFT). The prevalence of AD in my country is between 0.2% and 5.98%, and the disease mostly occurs in people over 60 years old. It increases with age, and it is estimated that there are more than 3.6 million AD patients in my country. In the survey of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61K31/365A61P25/28
CPCA61K31/34A61P25/28
Inventor 冯亦璞王晓良彭英杨靖华
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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