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Application of biphenyl cyclooctene containing substance in the process for preparing Alzheimer disease treating medicine

A technology for Alzheimer's disease and biphenylcyclooctene, which is applied to the application field of substances containing biphenylcyclooctene structure in the preparation of drugs for treating Alzheimer's disease, so as to facilitate clinical application and facilitate the treatment of diseases Effect

Inactive Publication Date: 2005-03-16
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no application of using one or several of them alone or in combination to make medicines for the treatment of Alzheimer's disease

Method used

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  • Application of biphenyl cyclooctene containing substance in the process for preparing Alzheimer disease treating medicine
  • Application of biphenyl cyclooctene containing substance in the process for preparing Alzheimer disease treating medicine
  • Application of biphenyl cyclooctene containing substance in the process for preparing Alzheimer disease treating medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The structure of schisandrin is shown in the figure below. When the 7 and 8 positions of the biphenyl cyclooctene core are methyl groups, the 1, 2, 3, 12, 13, and 14 positions are methoxy groups, and the 9 positions are hydroxyl groups, it is the structure of schisandrin.

[0022]

Embodiment 2

[0024] The structure of Schizandrin A is shown in the figure below. When the 7 and 8 positions of the biphenyl cyclooctene core are methyl groups, and the 1, 2, 3, 12, 13, and 14 positions are methoxy groups, it is the structure of Schisandrin A.

[0025]

Embodiment 3

[0027] The structure of Schizandrin B is shown in the figure below. When the 7 and 8 positions of the biphenyl cyclooctene core are methyl, the 1, 12, 13, and 14 positions are methoxy, and the 2-3 positions are methylenedioxy, that is the structure of Schisandrin B.

[0028]

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PUM

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Abstract

The invention discloses the application of biphenyl cyclooctene containing substance in the process for preparing Alzheimer disease treating medicine, wherein the substance has the formula disclosed in the specification. The biphenyl cyclooctene containing substance can effectively reduce the output of Abetta, suppress the formation of aged speckle, improve the learning and memory capability for the modeled mouse, thus achieving the goal of treating and delaying AD disease.

Description

technical field [0001] The invention relates to the application of a class of substances containing biphenyl cyclooctene structure in the preparation of medicines for treating Alzheimer's disease. Specifically, one or more of the substances containing biphenyl cyclooctene structure are used as main raw materials to prepare various medicines for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD), also known as senile dementia, is a degenerative brain disease characterized by progressive cognitive dysfunction and memory impairment. It is manifested as comprehensive and persistent mental decline, including memory, calculation, abstract thinking ability and language function decline, emotional and behavioral abnormalities, loss of work ability and independent living ability. Senile plaques (senile plaque, SP), neurofibrillary tangles (neurofibrillary tangle, NFT) and loss of basal forebrain cholinergic neurons are the main pathological changes ...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61K31/09A61K31/36A61P25/28
Inventor 罗焕敏肖飞李晓光
Owner JINAN UNIVERSITY
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