Transmission system of medicine containing trehalose and hyaluronic acid for eye part and its preparation method

A delivery system, hyaluronic acid technology, applied in the field of pharmaceuticals, can solve problems such as sticky eyes, frequent eye drops, short-term effect, etc.

Inactive Publication Date: 2005-08-10
OCEAN UNIV OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking eye drops as an example, although the preparation of traditional eye drops is relatively simple, there are obvious disadvantages: after eye drops, the drug is immediately diluted by the tears in the conjunctival sac and is quickly eliminated from the lacrimal duct. Low utilization, short-term effect, frequent eye drops are often required, and it is difficult for the liquid to reach the posterior segment of the eye
[0019] Non-Newtonian fluid characteristics: Although synthetic polymers and other substances can increase the viscosity of the liquid medicine and prolong the residence time of the liquid medicine on the ocular surface to improve the curative effect, the synthetic polymer solution used is basically a Newtonian fluid. To a certain extent, it will make the eyes feel sticky and uncomfortable

Method used

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  • Transmission system of medicine containing trehalose and hyaluronic acid for eye part and its preparation method
  • Transmission system of medicine containing trehalose and hyaluronic acid for eye part and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The ophthalmic drug delivery system of the present invention contains 100 ml of trehalose 1.5 g, sodium hyaluronate 0.10 g, sodium chloride 0.70 g, borax 0.05 g, and the rest is purified water.

Embodiment 2

[0037] The ophthalmic drug delivery system of the present invention contains 100 ml of trehalose 1.0 g, sodium hyaluronate 0.10 g, sodium chloride 0.75 g, borax 0.05 g, ethylparaben 0.03 g, and the rest is purified water.

Embodiment 3

[0039] The ocular drug delivery system of the present invention contains 100 ml of trehalose 1.5, sodium hyaluronate 0.10, chloramphenicol 0.68 g, sodium chloride 0.68 g, borax 0.05 g, ethylparaben 0.03 g, and the rest is purified water.

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PUM

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Abstract

An ophthalmic medicine delivery system for preventing and treating xerophthalmia, conjunctivitis, keratitis, corneal ulcer, etc contains proportionally trehalose, hyaluronic acid, and other pharmacologically active components. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to an ophthalmic drug delivery system (delivery system) containing trehalose and hyaluronic acid and a preparation method thereof, belonging to the technical field of pharmaceuticals. Background technique: [0002] The dosage forms of topical ophthalmology mainly include eye drops (accounting for about 90%), and eye ointments, injections, gels, etc. in addition. Taking eye drops as an example, although the preparation of traditional eye drops is relatively simple, there are obvious disadvantages: after eye drops, the drug is immediately diluted by the tears in the conjunctival sac, and is quickly eliminated from the lacrimal duct. The utilization is low, the effect is short-lived, frequent eye drops are often required, and it is difficult for the liquid medicine to reach the posterior segment of the eye. In addition, some eye drops also have shortcomings such as strong irritation or instability or high systemic toxicity. Althou...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K47/36A61P27/02
Inventor凌沛学管华诗
OwnerOCEAN UNIV OF CHINA