Protein marked by Tc-99 capable of specifically combined with GnRH-receptor expressed cancer cell

Abstract

The invention relates to a protein in vivo detection agent for detecting the surface receptor types and cancer positions of the oncocyte in human body, which comprises specifically recognizing and expressing the paraprotein use technetium-99 label of the GnRH receptor's oncocyte, thus producing twinkling images in human body. The paraprotein is the guided fusion protein comprising natural GnRH, GnRH mutant, the PE toxin derivatives.

Description

1. Technical field [0001] Cancer is still a serious threat to human health, with high morbidity and mortality. There are three main methods of traditional treatment for cancer: chemotherapy, radiotherapy and surgery. Surgical therapy is limited to the early stage. Although chemotherapy and radiotherapy are effective, their serious side effects limit the use of large doses and long-term applications of this method, which greatly affects their therapeutic effect. [0002] Therefore, at this stage, people are committed to researching a new method of treating tumors with low toxicity and high efficiency, which is to eliminate the shortcomings of radiotherapy and chemotherapy methods that kill tumor cells while also killing a large number of normal cells, specifically killing tumor cells, and killing tumor cells. Low or no toxicity to normal cells. This method is the application of targeting molecules, including ligands of receptors overexpressed on the surface of tumor cells and...

AI Technical Summary

Problems solved by technology

The advantages of other radionuclides used in the prior art are not as good as Tc-99m, because these radionuclides have longer physical half-lives, resulting in more radiation absorbed by the patient (eg Indium-111)

Or, the radiation energy of some other radionuclides is significantly lower (such as iodine-125) or significantly higher than (such as iodine-131) Tc-99m, so it is not suitable for the quality requirements of scintigraphic imaging. Suitable radionuclides cannot be produced with on-site generators

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