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Oils enriched with diacylglycerols and phytosterol esters for use in the reduction of blood cholestrol and triglycerides

A technology of phytosterol esters and phytosterol esters, applied in the fields of edible oil/fat, application, food science, etc., can solve problems such as no proof or discussion

Inactive Publication Date: 2011-05-11
ENZYMOTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it is commented in this patent that a synergistic effect on lipid metabolism can be expected when the amount of diacylglycerol exceeds 80% wt, such effect is not demonstrated or discussed in this patent

Method used

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  • Oils enriched with diacylglycerols and phytosterol esters for use in the reduction of blood cholestrol and triglycerides
  • Oils enriched with diacylglycerols and phytosterol esters for use in the reduction of blood cholestrol and triglycerides
  • Oils enriched with diacylglycerols and phytosterol esters for use in the reduction of blood cholestrol and triglycerides

Examples

Experimental program
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Effect test

preparation example Construction

[0107] The preparation of pharmaceutical compositions is well known in the art, see, for example, US Patents 5,736,519, 5,733,877, 5,554,378, 5,439,688, 5,418,219, 5,354,900, 5,298,246, 5,164,372, 4,900,549, 4,755,383, 4,639,435, 4,457,917 and 4,064,236. The combination used in the present invention can preferably be mixed with excipients, carriers and / or diluents, and any preservatives, etc. The pharmaceutically acceptable excipients are well known in the art, see, for example, the aforementioned US patents. Examples of excipients include glucose, mannitol, inositol, sucrose, lactose, fructose, starch, corn starch, microcrystalline cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, polyvinylpyrrolidone and the like. Optionally, thickeners such as natural colloids, cellulose derivatives, acrylic polymers or ethylene polymers can be added.

[0108] Preferably, the pharmaceutical composition is provided as a liquid, solid or semi-solid. Preferably, the liquid formu...

Embodiment 1

[0151] Olive oil, olive oil + plant sterols and olive oil MultOil in E 0 Antioxidant effect against lipid peroxidation of macrophages in mice

[0152] As mentioned above, oxidative stress is involved in the pathogenesis of atherosclerosis. Atherosclerosis is associated with lipid peroxidation in plasma LDL and arterial cells including macrophages [Aviram M. (2000) Free. Radic. Res. 33: S85-97; Aviram M. and Fuhrman B. (1998) Mol. Cell. Biochem. 188:149-159]. Under oxidative stress, the peroxide content of macrophages increases, and the macrophages produce reactive oxygen species, leading to increased atherosclerosis [Plump A.S. et al. (1992) Cell 71:343-353].

[0153] Apolipoprotein E deficiency (E 0 ) Mice are widely used as animal models of atherosclerosis because they develop severe hyperlipidemia and atherosclerotic damage when they eat a chow diet. In addition, E 0 In mice, accelerated atherosclerosis is associated with increased lipid peroxidation of plasma lipoproteins and...

Embodiment 2

[0171] The absence of apolipoprotein E in atherosclerosis (E 0 ) The effect of MultOil-c and MultOil-f on the atherosclerosis of lipoproteins and macrophages and the development of atherosclerosis in the mouse model. Apolipoprotein E deletion (apoE 0 ) Mice are 8 weeks old. They were randomly assigned to the groups described below (5 mice per group). The mice received regular solid food, in addition, they were fed as follows (by tube feeding), once every three days:

[0172] Group I :

[0173] 1. Placebo group: did not receive any additional oil.

[0174] 2. Canola oil group (control): 60μl canola oil was fed.

[0175] 3. MultOil-c group: feed with 60μl MultOil-c.

[0176] Group II :

[0177] 1. Placebo group: did not receive any additional oil.

[0178] 2. MultOil-f group: feed with 60μl MultOil-f.

[0179] Each mouse consumes about 5mL water / day and 5g solid food / day

[0180] Oil preparations for feeding

[0181] The amount of MultOil-c and MultOil-f fed to mice is based on the foll...

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Abstract

The present invention relates to the use of a composition comprising a combination of diacylglycerol(s) (DAG), mainly 1,3-diacylglycerol(s), and phytosterol and / or phytostanol ester(s) (PSE) dissolved or dispersed in edible oil and / or edible fat, in the manufacture of nutritional supplements and orally administrable pharmaceutical preparations which are capable of reducing blood levels of both cholesterol and triglycerides and / or for lowering serum, serum LDL and macrophage oxidation levels, inhibiting the formation of foam cells and / or preventing the deleterious effects generated by lipid-induced oxidative stress. In addition, the composition of the invention, as well as the pharmaceutical preparations thereof, is suitable for the treatment and prevention of conditions related to atherosclerosis, such as cardiovascular disease (CVD), coronary heart disease (CHD) and diabetes mellitus.

Description

Invention field [0001] The present invention relates to the use of a composition in the manufacture of nutritional supplements and oral pharmaceutical preparations. The composition contains diacylglycerol (DAG) dissolved or dispersed in edible oil and / or edible fat, mainly 1,3-diglycerol A combination of acylglycerol, and plant sterol esters and / or phytostanol esters (PSE), the nutritional supplements and oral pharmaceutical preparations can reduce the serum levels of both cholesterol and triglycerides, and also exhibit LDL- Antioxidant properties, and it is suitable for the treatment and prevention of cardiovascular disease (CVD) and coronary heart disease (CHD). Background of the invention [0002] All publications mentioned from the beginning to the end of this application are hereby incorporated by reference, including all references cited therein. [0003] Coronary artery disease (such as atherosclerosis) is the main cause of morbidity and mortality in the West. Its pathogene...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/30A61K31/20A61K31/575A61K31/56A23D9/013A61P9/00A23L
Inventor D·普拉特D·佩尔勒德A·舒尔曼
Owner ENZYMOTEC
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