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Medicine and bacterium composition for treating alcoholic liver injury as well as preparation method and application of composition

A technology of alcoholic liver injury and composition, which is applied in the field of medicine, can solve the problems of low abundance and low survival rate, and achieve the effects of reducing content, reducing accumulation, and relieving inflammation

Inactive Publication Date: 2021-06-15
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many people do not have Akkermansia Muciniphila bacteria in their intestines or the abundance is very low, and the survival rate of Akkermansia Muciniphila bacteria in the intestines is low, so the effect of supplementing probiotics alone is not very ideal

Method used

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  • Medicine and bacterium composition for treating alcoholic liver injury as well as preparation method and application of composition
  • Medicine and bacterium composition for treating alcoholic liver injury as well as preparation method and application of composition
  • Medicine and bacterium composition for treating alcoholic liver injury as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] (1) Preparation of Lycium barbarum puree: The high-quality Lycium barbarum was pulverized by ultrafine pulverization method, the speed of ultrafine pulverizer was 340r / min, the ball-to-material ratio was 7, and the pulverization time was 2h to obtain Lycium barbarum powder. Then add 40% water of wolfberry powder mass for mixing and beating, and sterilize at 110°C for instant high temperature to obtain wolfberry puree;

[0033] (2) Preparation of Akkermansia Muciniphila bacteria: According to the HACCP quality system, the bacteria were cultivated using a food-grade medium, and fermented under anaerobic conditions at 37° C. for 40 hours to obtain Akkermansia Muciniphila bacteria for use;

[0034] (3) Preparation of fruit pulp: wash the fruit raw materials twice or take the pulp, blueberry, kiwi fruit and apple are mixed according to the mass ratio of 8:6:3 for beating, and 0.2% of the total mass of the pulp is added to the pulp after beating Cellulase and 0.25% pectinase,...

Embodiment 2

[0041] (1) Preparation of Lycium barbarum puree: Fresh Lycium barbarum fruit was washed, directly beaten, and sterilized at 110°C to obtain Lycium barbarum puree;

[0042] (2) Preparation of Akkermansia Muciniphila bacteria: According to the HACCP quality system, the bacteria were cultivated using a food-grade medium, and fermented under anaerobic conditions at 37° C. for 40 hours to obtain Akkermansia Muciniphila bacteria for use;

[0043] (3) Pretreatment of fruit raw materials: after washing the fruit raw materials twice, take the pulp, mix blueberries, kiwis and apples according to the mass ratio of 8:6:4 for beating, and add 0.2% fiber of the total mass of pulp to the pulp after beating Sulfase and 0.25% pectinase, the enzymolysis temperature is 50-55°C, and the enzymolysis time is 2-2.5h. After colloidal grinding, fresh fruit pulp is obtained, and the fresh fruit pulp is filtered, and sterilized at 110° C. to obtain clarified fruit juice for later use;

[0044] (4) Prep...

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Abstract

The invention discloses a medicine and bacterium composition for treating alcoholic liver injury and a preparation method and application of the composition. According to the invention, proliferation of Akkermansia Muciniphila bacteria in intestinal tracts is promoted through specificity of Chinese wolfberry fruits, meanwhile, the Akkermansia Muciniphila bacteria can decompose substances such as polysaccharide in the Chinese wolfberry fruits into small-molecule active substances, and absorption of the intestinal tracts of the human body and exertion of activity are better facilitated. Functional components such as lycium barbarum polysaccharide, betaine, vitamins and various trace elements in the Chinese wolfberry fruits can remove oxygen free radicals in the body and recover the balance of oxidation and anti-oxidation systems of the body, and the lactobacillus fermented juice is used for assisting in enhancing and regulating the immunity of the human body, resisting oxidation and inflammation and improving the taste of the composition.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicinal-bacteria composition for treating alcoholic liver injury, a preparation method and application thereof. Background technique [0002] Alcoholic liver disease from heavy alcohol consumption is a global problem and the seventh leading risk factor for death and disability. After drinking alcohol, the liver metabolic enzyme system converts ethanol into acetaldehyde, and acetaldehyde is oxidized by dehydrogenase to generate acetic acid, and finally metabolized into carbon dioxide and water to be excreted outside the body. After drinking a lot of alcohol, a large amount of acetaldehyde produced can stimulate the production of adrenaline, norepinephrine, etc., manifested as flushing, dizziness, headache, and rapid heart rate. Severe ethanol poisoning manifests as lethargy, low blood pressure, slow breathing, rapid heart rate, and even death. Alcoholic liver in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K35/747A61P1/16A61P29/00A61P39/06
CPCA61K35/747A61K36/185A61K36/45A61K36/73A61K36/815A61K2236/15A61K2236/19A61K2236/31A61P1/16A61P29/00A61P39/06A61K2300/00
Inventor 耿燕许正宏陆震鸣任怡琳郭琳段文慧史劲松
Owner JIANGNAN UNIV
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