Oils enriched with diacylglycerols and phytosterol esters for use in the reduction of blood cholestrol and triglycerides and oxidative stress
A technology of phytosterol esters and phytostanol esters, applied in edible oil/fat, application, food science, etc., can solve problems such as no proof or discussion
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[0107] 药物组合物的制备是本领域公知的,参见,例如,US专利5,736,519,5,733,877,5,554,378,5,439,688,5,418,219,5,354,900,5,298,246,5,164,372,4,900,549,4,755,383,4,639,435,4,457,917和4,064,236。 The combination used in the present invention can preferably be mixed with excipients, carriers and / or diluents, and any preservatives, etc. Pharmaceutically acceptable excipients are known in the art, see for example the above-mentioned US patents. Examples of excipients include dextrose, mannitol, inositol, sucrose, lactose, fructose, starch, corn starch, microcrystalline cellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, and the like. Optionally, thickeners such as natural colloids, cellulose derivatives, acrylic polymers or vinyl polymers, etc. may be added.
[0108] The pharmaceutical composition is preferably presented as a liquid, solid or semi-solid. Liquid preparations are preferably presented as aqueous suspensions, oily suspensions or microencapsulated compositions. S...
Embodiment 1
[0150] Olive Oil, Olive Oil + Phytosterols and Olive Oil MultOil in E 0 Antioxidant effects against macrophage lipid peroxidation in mice
[0151] As mentioned above, oxidative stress is involved in the pathogenesis of atherosclerosis. Atherosclerosis is associated with plasma LDL and lipid peroxidation in arterial cells, including macrophages [Aviram M. (2000) Free. Radic. Res. 33:S85-97; Aviram M. and Fuhrman B. (1998) Mol. Cell. Biochem. 188:149-159]. Under oxidative stress, macrophage superoxide levels increase, and macrophages produce reactive oxygen species, leading to increased atherogenesis [Plump A.S. et al. (1992) Cell 71:343-353].
[0152] Apolipoprotein E deficiency (E 0 ) mice are widely used as animal models of atherosclerosis because they develop severe hyperlipidemia and atherosclerotic lesions when fed solid food (chow diet). In addition, E 0 Accelerated atherosclerosis in mice is associated with increased lipid peroxidation of plasma lipoproteins and art...
Embodiment 2
[0170] Atherosclerotic apolipoprotein E deficiency (E 0 ) Effects of MultOil-c and MultOil-f on lipoprotein and macrophage atherosclerosis and on atherosclerosis development in a mouse model. Deficiency of apolipoprotein E (apoE 0 ) mice were 8 weeks old. Randomly assigned to the groups described below (5 mice per group). Mice received regular solid chow and, in addition, were fed (by gavage) once every three days as follows:
[0171] Group I :
[0172] 1. Placebo group: did not receive any additional oil.
[0173] 2. Canola oil group (control): fed with 60 μl of canola oil.
[0174] 3. MultOil-c group: fed with 60 μl MultOil-c.
[0175] Group II :
[0176] 1. Placebo group: did not receive any additional oil.
[0177] 2. MultOil-f group: fed with 60 μl MultOil-f.
[0178] Each mouse consumes approximately 5 mL of water / day, and 5 g of solid food / day
[0179] Oil preparations for feeding
[0180] The amount of MultOil-c and MultOil-f fed to mice was based on t...
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