Puerariae Decoction mixture preparing process

A manufacturing process, the technology of Gegen Decoction, which is applied in the field of manufacturing processes of traditional Chinese medicine mixtures, can solve the problems of easy precipitation, poor stability of traditional Chinese medicine preparations, and decline in effective ingredients, and achieves the effects of accurate effective ingredients, stable storage quality, and accurate curative effect.

Active Publication Date: 2006-08-02
南京星银药业集团有限公司
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Problems solved by technology

At this time, the above-mentioned various components will undergo hydrolysis and polymerization under the influence of light, air and temperature to form precipitates, and the pH value will drop, which is the reason for the poor stability of traditional Chinese medicine preparations.
When using the alcohol precipitation process, part of the active ingredients in the liquid medicine will also dissolve in ethanol, resulting in a decrease in the active ingredients
Difficult removal of ineffective ingredients is an important reason for the poor appearance of the liquid medicine, easy precipitation during storage, and poor product stability

Method used

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  • Puerariae Decoction mixture preparing process

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Embodiment 1

[0015] Selected formula: Pueraria 13.3%; Ephedra 10%; Guizhi 6.7%; Licorice 6.7%, Radix Paeoniae Alba 6.7%; Jujube 6.7%; Ginger 10%. The medicinal materials of the above formula are leached for 5-6 hours during water extraction, the active ingredients are leached by water, and the ineffective ingredients, such as gums, starches, proteins, etc., are present in the water extract at the same time. ①If the total amount of medicinal materials is 100Kg, the water extract is about 100Kg (concentrated treatment). ②For ultrafiltration, add about 300Kg of water, the total amount after adding water is 400Kg, and the ultrafiltration operation takes 1.25 hours. ③ When nanofiltration is concentrated, about 300Kg of water is separated and discarded, and it takes about 30 minutes. The concentration of the concentrated solution is 1:1, that is, 1 gram of the extract is equivalent to 1 gram of the original medicinal material. ④In this process, during ultrafiltration and nanofiltration, there i...

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Abstract

The present invention relates to Chinese medicine mixture preparation, and is especially the preparation process of Puerariae Decoction mixture. The preparation process includes the steps of leaching, separating, purifying, and concentrating. The preparation process features its effective Chinese medicine component separating step, which is ultrafiltering separation adopting organic membrane or inorganic ceramic membrane of molecular weight 10-50 KDa; and its concentrating step, which includes nanofiltering purification and concentration with organic membrane of molecular weight 150-200 Da. Thus prepared Puerariae Decoction mixture is clear, transparent, reddish brown and accurate in effective components, and has unique smell, high storage stability and accurate curative effect.

Description

[0001] Involved areas [0002] The invention relates to a manufacturing process of a traditional Chinese medicine mixture, in particular to a manufacturing process of a Pueraria decoction mixture. Background technique [0003] Traditional Chinese medicine preparations have complex ingredients. In addition to effective substances such as alkaloids, glycosides, and flavonoids, a large number of ineffective substances such as starch, tree limbs, and proteins also appear during the manufacturing process. In the conventional production process, it is often impossible to ensure the accurate separation of active ingredients, and it is also impossible to completely remove ineffective ingredients. Therefore, when conventional production techniques are used to manufacture traditional Chinese medicine mixtures, the appearance of the product is poor, such as the color of the liquid is too dark, the liquid is turbid, and it is difficult for patients to accept it. At the same time, the inte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/488A61K9/08A61P29/00A61P31/00
Inventor 刘利根王俊卿李永胜李鹏周建林郭衍祺
Owner 南京星银药业集团有限公司
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