Human leucocyte antigen DR4 subtype protein agonist
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- PEKING UNIV
- Publication Date
- 2007-03-28
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to novel uses of compounds. Background technique
[0002] Human leukocyte antigen molecule (HLA)-DR is the most representative type of human major histocompatibility complex (MHC) class II molecules, which can detect foreign polypeptide antigens through T cells restricted by MHC class II molecules. Recognition plays an important role in the body's immune response and immune regulation. In recent years, a large number of related studies have been conducted on HLA-DR and T cell receptors, and it has been found that they affect the pathogenesis of various malignant diseases such as rheumatoid arthritis, gastric cancer, chronic hepatitis B, and tuberculosis (Stastny P.Association of the B -cell alloantigen DRw4 with rheumatoid arthritis. N Engl JMed 1978, 298: 869-871.; Gregersen PK, Silver J, Winchester RJ. 1205-1213.; Thomson W, Harrison B, Ollier B, Wiles N, Payton T, Barrett J, Symmons D, Silman A. Quantifying the exact ...