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Human leucocyte antigen DR4 subtype protein agonist

An antagonist, HLA-DR4 technology, applied in the field of compounds, to achieve the effect of broad application prospects

Inactive Publication Date: 2007-03-28
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of compound is synthesized and isolated by combinatorial synthesis, and there is no relevant report on its use

Method used

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  • Human leucocyte antigen DR4 subtype protein agonist
  • Human leucocyte antigen DR4 subtype protein agonist
  • Human leucocyte antigen DR4 subtype protein agonist

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Experimental program
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Embodiment 1

[0019] 1. Experimental materials

[0020] According to the structure of formula I, five compounds conforming to the structural formula in Table 1 were purchased (the samples were purchased from Shanghai Sinopharm Chemical Reagent Co., Ltd. (www.sinoreagent.com)), and dissolved in DMSO as a solvent.

[0021] Table 1 Compound list

[0022] CII was synthesized by conventional solid-phase synthesis technology and dissolved in water; antigen-presenting cells APC used Priess cells, HLA-DR4-restricted T cells used 3838 cells (Fridkis-HareliM, Rosloniec EF, FuggerL, Strominger JL.Synthetic peptides that Inhibit binding of the collagen type II261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and-DR4 molecules and collagen-specific T-cell responses. Hum Immunol 2000, 61(7): 640-650.).

[0023] 2. Experimental method

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PUM

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Abstract

The present invention discloses an antagonist of human leukocyte antigen DR4 subtype protein. Said invention also provides its chemical structure formula and its concrete application range.

Description

technical field [0001] The present invention relates to novel uses of compounds. Background technique [0002] Human leukocyte antigen molecule (HLA)-DR is the most representative type of human major histocompatibility complex (MHC) class II molecules, which can detect foreign polypeptide antigens through T cells restricted by MHC class II molecules. Recognition plays an important role in the body's immune response and immune regulation. In recent years, a large number of related studies have been conducted on HLA-DR and T cell receptors, and it has been found that they affect the pathogenesis of various malignant diseases such as rheumatoid arthritis, gastric cancer, chronic hepatitis B, and tuberculosis (Stastny P.Association of the B -cell alloantigen DRw4 with rheumatoid arthritis. N Engl JMed 1978, 298: 869-871.; Gregersen PK, Silver J, Winchester RJ. 1205-1213.; Thomson W, Harrison B, Ollier B, Wiles N, Payton T, Barrett J, Symmons D, Silman A. Quantifying the exact ...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K31/496A61K31/4184A61K31/426A61P29/00A61P19/02A61P35/00A61P1/16A61P31/20
Inventor 来鲁华刘莹刘振明李博栗占国李霞张翠华陈巧林
Owner PEKING UNIV
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