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Preparation method of the Chinese traditional medicinal composition granules for treating galactophore disease and its products

A technology for traditional Chinese medicine granules and breast diseases, which is applied to medical preparations containing active ingredients, diseases, and pharmaceutical formulas, etc. It can solve the problem that the drying temperature cannot be effectively controlled, it is difficult to fully decoct the active ingredients, and the loss of active ingredients is large, etc. problem, to achieve the effect of improved bioavailability, good dissolution rate and simplified production process

Active Publication Date: 2010-05-12
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

What this method adopts is decocting under normal pressure, and decocting under normal pressure is difficult to fully decoct the active ingredient of the seed medicinal material such as wangbuliuxing; The drying temperature in the drying process of the extrusion granulation method cannot be effectively controlled, and the active ingredients in the drug are greatly lost during the granulation drying process, and the mixing, granulation, and drying processes of the extrusion granulation method must be separated. step completion, low production efficiency

Method used

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  • Preparation method of the Chinese traditional medicinal composition granules for treating galactophore disease and its products
  • Preparation method of the Chinese traditional medicinal composition granules for treating galactophore disease and its products
  • Preparation method of the Chinese traditional medicinal composition granules for treating galactophore disease and its products

Examples

Experimental program
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Effect test

Embodiment 1

[0035] [Example 1] Preparation of granules

[0036] The raw materials were weighed according to the following weights: 412.5g of orange leaves, 412.5g of salvia miltiorrhiza, 275g of saponins, 275g of buliuxing, 275g of toosendan, and 275g of earthworm.

[0037] Add water to decoct tangerine leaves, salvia miltiorrhiza, saponins, wangbuliuxing and toosendan, add steam pressure of 0.1-0.4Mpa, decoct twice, each time for 1 hour, combine decoctions, filter, and concentrate the filtrate To 138ml, add earthworm, mix, reflux extraction with 70% ethanol twice, the first time for 2 hours, the second time for 1 hour, filter, combine the filtrate, recover the ethanol and concentrate to a thick paste, add sucrose, starch, dextrin Appropriate amount, mixed evenly, boiling granulation, the temperature of the drying air flow is controlled at 70-80°C, drying, granulation, packaging, and the product is ready.

Embodiment 2

[0038] [Example 2] Preparation of granules

[0039] The raw materials were weighed according to the following weights: 412.5g of orange leaves, 412.5g of salvia miltiorrhiza, 275g of saponins, 275g of buliuxing, 275g of toosendan, and 275g of earthworm.

[0040] Add water to decoct tangerine leaves, salvia miltiorrhiza, saponins, wangbuliuxing and toosendan, add steam pressure of 0.1-0.4Mpa, decoct twice, each time for 1 hour, combine decoctions, filter, and concentrate the filtrate To 138ml, add earthworm, mix, reflux extraction with 70% ethanol for two times, the first time for 2 hours, the second time for 1 hour, filter, combine the filtrate, recover the ethanol and concentrate to a thick paste, add 500g of sucrose and starch, paste Fine amount, mixing, boiling granulation, drying air temperature controlled at 70 ~ 80 ℃, drying, granulation, packaging, to get.

Embodiment 3

[0041] [Example 3] Preparation of granules

[0042] The raw materials were weighed according to the following weights: 104g of orange leaves, 104g of salvia miltiorrhiza, 70g of saponins, 70g of buliuxing, 70g of toosendan, and 70g of earthworm.

[0043] Add water to decoct tangerine leaves, salvia miltiorrhiza, saponins, wangbuliuxing and toosendan, add steam pressure of 0.1-0.4Mpa, decoct twice, each time for 1 hour, combine decoctions, filter, and concentrate the filtrate To 550ml, add earthworm, mix, reflux extraction with 70% ethanol twice, the first time for 2 hours, the second time for 1 hour, filter, combine the filtrate, recover the ethanol and concentrate to a thick paste, add 125g of sucrose and starch, paste Fine amount, mixing, boiling granulation, drying air temperature controlled at 70 ~ 80 ℃, drying, granulation, packaging, to get.

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Abstract

This invention provides a preparing method of the Chinese traditional medicinal composition granules for treating galactophore disease. The method consists of the following steps: (1)Take tangerine leafs, radices salviae, Chinese honeylocust, cowherb seed, Chinaberry fruit and earthworm. (2)Fry the tangerine leafs, radices salviae, Chinese honeylocust, cowherb seed,, Chinaberry fruit in water separately, combine the fried liquids, filter them and have the filtered liquid concentrated. (3)Add earthworm to concentrated liquid obtained in step (2), mix it even. (4)Use 60-90% ethanol to abstract the concentrated liquid obtained in step (3), filter the abstracted liquid, reclaim ethanol and concentrate it till it forms into thick cream. (5)Add one or manifold of the following ingredients: canesugar, lactose, xylitol and tangerine sugar, add an amount of starch, starch gum, then mix them even, boil to make them into the form of granules. The method is easy operated with low production costsand high efficiency. This invention also provides a kind of the Chinese traditional medical granules made by the above preparing method.

Description

technical field [0001] The invention relates to a preparation method of traditional Chinese medicine granules for treating breast diseases and a product thereof, belonging to the technical field of traditional Chinese medicines. Background technique [0002] The theory of traditional Chinese medicine believes that breast distension and hyperplasia are caused by the poor circulation of Qi and blood in the liver meridian. "Danxi Heart Method" said: "Qi and blood are in harmony, and all diseases will not arise. Once there is depression, all diseases will arise. The diseases of the ancient people are mostly born from depression." To vent and hide blood. Emotional depression, wood loss, liver failure, resulting in stagnation of liver qi; qi is handsome in blood, when qi moves, blood flows, and qi stagnation leads to blood stasis, and the circulation of qi and blood accumulates in the breast, stomach and Collateral meridians are obstructed, which can lead to pain and cause breas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K9/16A61P15/14A61K35/64A61K35/62
Inventor 付立家
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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