Artemisia dubia Wall. ex Bess oil drop pill having sputum-dissolving cough-stopping asthma-relieving functions and preparation process thereof

A technology for relieving asthma, reducing phlegm and relieving cough, applied to medical preparations containing active ingredients, pill delivery, pharmaceutical formulas, etc. Lowering and other issues

Inactive Publication Date: 2007-05-30
王丽娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the active ingredients of the Artemisia sativa oil drop pills are volatile ingredients, the roundness rate, time limit for dissolution and hardness index of the drop pills are not easy to meet the requirements of the preparation when preparing the drop pills, and the preparation is in the storage process, due to the volatilization of the active ingredients. Its content is greatly reduced, and it has become a major problem in the preparation of sagebrush oil dripping pills

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] (a) According to the weight ratio of medicinal ingredients and matrix of 1:7, weigh 25000g of Artemisia oxtail (wherein, 500g of Artemisia oxtail medicinal material can be extracted by steam distillation to obtain 1g of volatile oil of Artemisia oxtail), extract the volatile oil according to steam distillation , re-distilled until the relative density of the volatile oil is 0.87, and set aside;

[0016] (b) Weigh 45g of Manshanhong oil, 5g of licorice extract, and 700g of polyethylene glycol (4000) respectively, place the base in a heating container and heat it to melt while stirring, then gradually add the active ingredients in stages and stir , until the molten liquid containing the medicinal ingredients and matrix is ​​obtained, and set aside;

[0017] (c) Adopt a self-made dripping pill machine, adjust the temperature control system of the dripping pill machine, keep the temperature of the dripper of the dropping pill machine at (75-90) °C, and make the temperature ...

Embodiment 2

[0021] (a) According to the weight ratio of medicinal ingredients and matrix of 1:5, weigh 25000g of Artemisia oxtail (wherein, 500g of Artemisia oxtail medicinal material can be extracted by steam distillation to obtain 1g of volatile oil of Artemisia oxtail), extract the volatile oil according to steam distillation , re-distilled until the relative density of the volatile oil is 0.87, and set aside;

[0022] (b) Take Vitex oil 30g, polyethylene glycol (4000) 500g and polyethylene glycol (20000) 45g, sodium stearate 15g respectively, place the matrix in the heating container and heat to melt while stirring, then Gradually add medicinal ingredients and stir until a molten liquid containing medicinal ingredients and matrix is ​​obtained, and set aside;

[0023] (c) Adopt a self-made dripping pill machine, adjust the temperature control system of the dripping pill machine, keep the temperature of the dripper of the dropping pill machine at (75-90) °C, and make the temperature gr...

Embodiment 3

[0028] (a) According to the weight ratio of medicinal ingredients and matrix 1:3, weigh 25,000g of Artemisia oxtail (wherein, 500g of Artemisia oxtail medicinal material can be extracted by steam distillation to obtain 1g of volatile oil of Artemisia oxtail), extract the volatile oil according to steam distillation , re-distilled until the relative density of the volatile oil is 0.87, and set aside;

[0029] (b) Take 1.0g of Tween-80, 60g of polyethylene glycol (6000) and 90g of polyethylene glycol (4000) respectively, place the matrix in a heating container and heat it to melt while stirring, and then gradually Add the medicinal ingredients and stir until a molten liquid containing the medicinal ingredients and the matrix is ​​obtained, and set aside;

[0030] (c) Adopt a self-made dripping pill machine, adjust the temperature control system of the dripping pill machine, keep the temperature of the dripper of the dropping pill machine at (75-90) °C, and make the temperature g...

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PUM

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Abstract

The invention discloses a medicinal composition having functions of resolving phlegm, relieving cough, and lowering the adverse rise of energy, thus being mainly used for treating chronic bronchitis. The composition is prepared into oral administration dripping pills comprising volatile oil extracted from Artemisia subdigitata Mattf. As the medicinal active constituent and medicinal carrying agent as the base material.

Description

technical field [0001] The invention relates to a sagebrush oil drop pill with the functions of resolving phlegm, relieving cough and relieving asthma, and also relates to a preparation method of the drop pill. Background technique [0002] Artemisia oxtail oil capsules are recorded in the part of the lung system (1) volume of the national standard internal medicine, which has the effect of reducing phlegm and relieving cough, reducing qi and relieving asthma. Chronic bronchitis is seen in the above-mentioned syndromes, and it is a commonly used oral preparation for clinical and family treatment of chronic bronchitis. Gelatin is mostly used as the capsule body material for the preparation of capsules. Due to the characteristics of gelatin and the preparation technology, the outer skin of the capsule is prone to aging during the storage of capsules, which will produce certain insoluble substances in the human body. Residues in the human body will have a certain impact on the...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/282A61K36/45A61K36/484A61K36/534A61K36/59A61K36/71A61K9/20A61P11/06A61P11/10A61P11/14A61K31/045
Inventor周玉新
Owner王丽娟