Pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, preparation process and quality control method thereof

A technology for cardiovascular and cerebrovascular diseases and compositions, which is applied in the direction of cardiovascular system diseases, drug combinations, and test drug preparations, etc., and can solve problems such as inapplicability to long-term use, undiscovered, and clinical application limitations

Inactive Publication Date: 2007-05-30
BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been found clinically that Codonopsis pilosula preparations are mostly pure traditional Chinese medicine preparations, with slow onset of action, long course of treatment, low bioavailability, and large fluctuations in curative effect; while troxerut...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1 of the present invention: Troxerutin 10g Codonopsis glycosides 30g

[0053] Take troxerutin and codonopsis total glycosides and add water for injection, stir to dissolve, filter, add 0.5% (W / V) activated carbon after the filtrate is boiled, keep slightly boiling for 30 minutes, filter slightly cold, adjust the pH value of the filtrate to 5.5~ 7.0, boil, refrigerate (4°C) overnight, coarse filter, fine filter; add mannitol and water for injection to make a 120mg / ml solution, mix with the above filtrate, filter, add water for injection to the specified amount, subpackage, and freeze Drying, pre-freezing temperature -45°C, pre-freezing time 10h; start vacuuming, and raise the temperature to -40°C, keep for 8h; and gradually increase the temperature to 10°C with a differential gradient within 12 to 72 hours, keep for 2h, and raise the temperature to 20°C ℃, keep for 2 hours, raise the temperature to 30 ℃, keep for 2 hours, and obtain the sterile block for injec...

Embodiment 2

[0054] Embodiment 2 of the present invention: Troxerutin 10g Codonopsis glycosides 5g

[0055] Take troxerutin and codonopsis total glycosides and add water for injection, stir to dissolve, filter, adjust the pH value of the filtrate to 5.5-7.0, add 0.5% activated carbon for needles, boil for adsorption, remove carbon, fine filter, and add injection to the filtrate Water to the specified amount, refrigerated overnight at 4°C, coarsely filtered, finely filtered, divided into ampoules, sterilized, divided into small volume injections containing 0.5 parts of Codonopsis glucosides and 1 part of troxerutin or Concentrated solution for injection.

Embodiment 3

[0056] Embodiment 3 of the present invention: Troxerutin 3g Codonopsis glycosides 15g

[0057] Take troxerutin and codonopsis total glycosides, add an appropriate amount of water for injection to dissolve, add a specified amount of glucose or sodium chloride to the filtrate, mix and dissolve, add 0.5% activated carbon for needles according to volume, boil, keep slightly boiling for 30 minutes, and filter slightly cold Add water for injection to the filtrate to an appropriate amount, adjust the pH value to 5.5-7.0, boil, refrigerate overnight at 4°C, coarse filter, fine filter, add water for injection to the full amount, sub-package, and sterilize to obtain 1 part of troxerut Dinghe glucoside or sodium chloride intravenous infusion of 5 copies of Codonopsis glucoside.

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, its preparing process and quality control method, wherein Troxerutin and Codonopsis pilosula glycosides are employed in combination to obtain various dose forms of injections and oral administration preparations. The composite preparation is mainly used for treating coronary disease, pulmonary heart disease, cerebral ischemia, thrombotic phlebitis, capillary vessel hemorrhage, nervous prostration and climacteric metancholia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cardiovascular and cerebrovascular diseases, a preparation method and a quality control method thereof, and belongs to the technical field of medicines. technical background [0002] At present, about 4 million people die from cardiovascular and cerebrovascular diseases in my country every year, accounting for more than 3 / 5 of the death toll, and it has become the primary factor threatening human health. Although there are a large number of Chinese and Western medicine interviews at present, with the continuous change of disease spectrum and the arrival of aging age, the current medicine continues to show its limitations. Therefore, research and development of medicines for the treatment of cardiovascular and cerebrovascular diseases are always Become the focus and hot spot of people's attention. [0003] Codonopsis pilosula has the functions of invigorating the middle and replenishing...

Claims

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Application Information

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IPC IPC(8): A61K36/344A61K31/7048A61K31/352A61K9/08A61K9/10A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61K9/70A61P9/10A61P9/00A61P15/14A61P25/20A61P11/00G01N30/02G01N33/15
Inventor 于文风
Owner BEIJING QI YUAN YI DE PHARMA RESEARCH CENTER
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