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Use of 7,16-pimaric dienoic acid for preparing Anti-AIDS medicine

A technology for anti-AIDS and sea pine, which is applied in the field of medicine and can solve problems such as unreported uses.

Inactive Publication Date: 2007-06-13
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, its use has not been reported so far

Method used

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  • Use of 7,16-pimaric dienoic acid for preparing Anti-AIDS medicine
  • Use of 7,16-pimaric dienoic acid for preparing Anti-AIDS medicine

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preparation example Construction

[0007] The preparation method of the present invention is as follows:

[0008] One, the preparation method of extracting 7,16-pimarinadienoic acid from Torreya aril:

[0009] 1. Extraction: after crushing, the aril of Torreya torreya is soaked with 5-8 times the amount of petroleum ether, percolated for 3 times, and then the dregs are extracted by percolation with 10 times the amount of 85% ethanol, and the extract is recovered to obtain the extract. After suspending the ointment with 2 times of water, extract 5 times with an equal amount of ethyl acetate, combine the ethyl acetate extracts, recover the solvent under reduced pressure, and obtain the ethyl acetate extract.

[0010] 2. Separation: carry out silica gel column chromatography on ethyl acetate extract, carry out gradient elution with petroleum ether: ethyl acetate = 9: 1 ~ 7: 3, thin-layer detection, collect the fraction containing the chemical component, and then pass through Purified by Sephadex LH-20 column chro...

Embodiment 1

[0032] Embodiment 1: the preparation of 7,16-pimaric dienoic acid

[0033] Take 6 kg of Torreya sinensis from Zhejiang, soak in 30 liters of petroleum ether for 3 days, then infiltrate, use 60 kg of 85% ethanol to extract the dregs, collect the ethanol leachate, recover under reduced pressure, and obtain 1.3 kg of ethanol extract , the extract was suspended with 2.6 kg, extracted with an equal amount of ethyl acetate to obtain an ethyl acetate extract, and the ethyl acetate was recovered under reduced pressure to obtain 620 grams of extract.

[0034] The above-mentioned extract was subjected to silica gel column chromatography, and about 30 liters of petroleum ether: ethyl acetate (9: 1 ~ 7: 3) was used for elution, and every 200 milliliters was 1 fraction, and the 110th to 130th fractions were combined and subtracted. The solvent was recovered under pressure, and the residue was subjected to gel Sephadex HL-20 column chromatography, and eluted with 5 liters of dichloromethane...

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Abstract

The present invention belongs to the field of medicine technology, and it relates to an application of 7,16-pimaradiene acid for preparing medicine for resisting AIDS. Its external active detection for resisting AIDS virus proteinase or integral proteinase shows that its median effective inhibition concentration IC50 for AIDS virus HIV-1 proteinase is 33.68 m g / ml, and the median effective inhibition concentration IC50 for AIDS virus HIV-1 integral proteinase is 45.79 mu g / ml, so that it can be used for preparing medicine for resisting AIDS.

Description

technical field [0001] The invention relates to the field of medicine, and relates to the application of 7,16-pimaratedienoic acid in the preparation of anti-AIDS drugs. Background technique [0002] Torreya grandis (Torreya grandis cv. Merrilli) is a plant of the genus Torreya of Taxaceae, and it is a tall tree growing in southern my country. Its seeds are Chinese torreya, a famous dried fruit. The outer layer of the seed has an aril, which is removed as waste during seed processing. A chemical component of 7,16-pipinediene was isolated from the aril, and its chemical structure was determined to be 7,16-pipinediene (G.MalallahM. Afzal, M. Kurian and S. Gulshan M: Impact of oil pollution on some desert plant, Environment International, 1998, 24(8): 919-924) has the following chemical structure [0003] [0004] But its use has not been reported so far. Contents of the invention [0005] The present invention provides an application of 7,16-pimaratedienoic acid in th...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61P31/18
Inventor 易杨华周大铮李玲刘宝姝
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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