Medicine composition for treating hepatic disease mainly

A technology of composition and medicine, applied in the field of medicine

Inactive Publication Date: 2007-06-27
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the use of wolfberry fruit or its extract, Angelica sinensis or its extract and glycyrrhizic acid or its pharmaceutically acceptable salts to prepare compatible prescriptions for the treatment of liver diseases.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0147] Example 1 Preparation, identification and content determination of Lycium barbarum polysaccharide

[0148] Preparation of Lycium Barbarum Polysaccharide

[0149] Take wolfberry medicinal material, add 80% ethanol to reflux and extract twice, each time for 2 hours, filter, and discard the filtrate after recovering ethanol. Add water to decoct the dregs three times, each time for 1 hour, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.10-1.12 (60°C), let it cool, let it stand in the refrigerator for 12 hours, centrifuge for 20 minutes, discard the precipitate, and take the For the supernatant, add concentrated hydrochloric acid to adjust the pH value to 1-2 under stirring, let it stand in the refrigerator for 12 hours, centrifuge for 20 minutes, discard the precipitate, take the supernatant, precipitate with 4 times the volume of ethanol, and refrigerate for 24 hours , and the precipitate was collected by filtration to obtain crud...

Embodiment 2

[0162] Example 2 Preparation, Identification and Content Determination of Angelica Polysaccharide

[0163] Preparation of Angelica polysaccharide

[0164] Take Angelica medicinal material, add 80% ethanol to reflux extraction twice, each time for 2 hours, filter, and discard the filtrate after recovering ethanol. Add water to decoct the dregs three times, each time for 1 hour, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.10-1.12 (60°C), let it cool, refrigerate and let it stand for 12 hours, centrifuge for 20 minutes, discard the precipitate, and take the For the supernatant, add concentrated hydrochloric acid to adjust the pH value to 1-2 under stirring, let it stand in the refrigerator for 12 hours, centrifuge for 20 minutes, discard the precipitate, take the supernatant, precipitate with 4 times the volume of ethanol, and refrigerate for 24 hours , and the precipitate was collected by filtration to obtain crude polysaccharide. A...

Embodiment 3

[0177] Example 3 Preparation and Content Determination of Lycium Barbarum Angelica Co-extract

[0178] Preparation of co-extracts from Lycium barbarum and Angelica sinensis

[0179] Take medlar and angelica medicinal materials, add 80% ethanol to reflux and extract twice, each time for 2 hours, filter, and discard the filtrate after recovering ethanol. Add water to decoct the dregs three times, each time for 1 hour, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.10-1.12 (60°C), let it cool, let it stand in the refrigerator for 12 hours, centrifuge for 20 minutes, discard the precipitate, and take the For the supernatant, add concentrated hydrochloric acid to adjust the pH value to 1-2 under stirring, let it stand in the refrigerator for 12 hours, centrifuge for 20 minutes, discard the precipitate, take the supernatant, precipitate with 4 times the volume of ethanol, and refrigerate for 24 hours , and the precipitate was collected by f...

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PUM

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Abstract

The present invention belongs to the field of medicine technology, and is especially one kind of medicine composition for treating liver diseases and its preparation process. The medicine composition is prepared with wolfberry fruit 50- 1000 weight portions, angelica 50-1000 weight portions, and glycyrrhizic acid or its pharmaceutically acceptable salt 1-50 weight portions; or with wolfberry fruit polysaccharide 2.5-50 weight portions, angelica polysaccharide 1-20 weight portions, and glycyrrhizic acid or its pharmaceutically acceptable salt 1-50 weight portions. It may be prepared into any pharmaceutically acceptable forms, preferably orally taken preparation and injection. It is used mainly for treating various liver diseases, including viral hepatitis, medicinal liver injury, fatty liver, alcohol liver, etc.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition mainly composed of wolfberry or its extract, angelica or its extract, glycyrrhizic acid or its pharmaceutically acceptable salt, and a preparation method thereof. 2. Background technology [0002] Hepatitis is a common and frequently-occurring disease. According to incomplete statistics, hepatitis patients and virus carriers account for 10% of the total population in my country. Among them, viral hepatitis is the main one, and viral hepatitis can be divided into: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Hepatitis is a kind of infectious disease, because of its widespread prevalence, great harm, and high incidence rate, it is one of the difficult diseases recognized both at home and abroad. China is a high prevalence area of ​​hepatitis B, more than 40% of people have been infected by hepatitis B virus (HBV), and m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K31/704A61P1/16A61P31/14
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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