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Cyclamin A and its preparation method and use thereof

A compound, hydroxyl technology, applied in the field of new medicine, can solve the problems such as anti-cancer, anti-inflammatory and analgesic activities that have not yet been seen

Inactive Publication Date: 2007-07-11
BEIJING ROCK PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there have been no reports on the anti-cancer, anti-inflammatory and analgesic activities of such chemical components

Method used

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  • Cyclamin A and its preparation method and use thereof
  • Cyclamin A and its preparation method and use thereof
  • Cyclamin A and its preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] Preparation of siclamin A

[0032] Pulverize 1kg of the whole plant of Oryza radix, extract with ethanol, extract 4 times with 4 liters of ethanol each time, combine the extracts, filter, concentrate to specific gravity D=1.2, put on 1200g column of AB-8 macroporous resin (column bed: φ50× 200), 10%-70% ethanol was used for gradient elution, and the eluted liquid was combined and evaporated to dryness to obtain 41 g of total saponins in the extract. The total saponins were loaded onto a 2000g silica gel column (column bed: φ150×1500), and eluted with a mixed solvent of n-butanol: acetic acid: water = 7:1:2. Obtain 18.23g of siclamin glycoside A.

[0033] Ciclarmin A is a white powder. 10%EtOH-H 2 SO 4 The test is red and black (heated), indicating the presence of sugar. FAB-MS mass spectrum (m / z[M+H] + ) to determine its molecular weight is 1074. Positive ion fast atom bombardment mass spectrometry gave the aglycon loss of hydroxyl peak as m / z 455, with m / z 133 (...

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Abstract

The invention discloses a Cyclamen A, its preparing process and use, as well as a group of compounds of formula I, wherein each group is defined in the specification. These compounds possesses good anticancer and anti-inflammatory actions. The invention also relates to the medicinal compositions containing these compounds, and their use in treating tumor and inflammatory diseases.

Description

technical field [0001] The invention belongs to the field of new medicine. The present invention relates to a novel compound siclamin glycoside A compound, a pharmaceutical composition containing the compound for treating cancer or inflammation, and an application of the compound in the preparation of anticancer or anti-inflammatory drugs. Background technique [0002] Ardisia mamillata Hance is a plant of the genus Ardisia mamillata Hance. In traditional Chinese medicine, it is believed to have the effects of clearing away heat and dampness, promoting blood circulation and stasis. According to the "Dictionary of Chinese Medicine", the plant can be used to treat pain, bruises, hemoptysis, sores, boils, swelling and pain. [0003] So far, there have been no reports of such chemical components having anticancer, anti-inflammatory, and analgesic activities. At the same time, since the vast majority of cancer patients, especially those in the advanced stage, suffer from severe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00C07J63/00A61K31/7048A61K36/185A61P29/00A61P35/00
Inventor 杨霁初侯海燕王海勇
Owner BEIJING ROCK PHARMA
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