Method and article for treatment of inflammatory disease
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Recently there has been increasing interest in electrobiological effects in humans. The use of low frequency electromagnetic fields to promote bone repair is well established. (See Pilla, “Low-intensity electromagnetic and mechanical modulation of bone growth and repair: are they equivalent?” J Orthrop Asc 2002; 7(3): 420-8). Electroporation, the use of high frequency, high voltage pulsed electrostimulation of cellular tissue to increase the permeability of the cell membrane has become well established and is used to enhance chemotherapy drug delivery (Neumann et al. “Fundamentals of electroporative delivery of drugs and genes” Bioelectrochem Bioenerg 1999 February; 48(1): 3-16; Gehl “Electroporation:theory and methods, perspectives for drug delivery, gene therapy and research”, Acta Physiol Scand 2003 April; 177(4); 437-47). Recent studies suggest low frequency electromagnetic fields reduce permeability of cell membranes ((Bordiushkov et al. “Structural-Functional changes in lymph...
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