Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis

US20050202019A1Inactive Publication Date: 2005-09-15NORTHWEST BIOTHERAPEUTICS INC
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
NORTHWEST BIOTHERAPEUTICS INC
Publication Date
2005-09-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.
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Description

1. FIELD OF THE INVENTION

[0001] The present invention relates to the identification of a novel role for the CXCR-4 gene in tumorigenesis, in particular primary brain, breast and colon tumorigenesis. The present invention is related to the role of CXCR-4 nucleic acids and polypeptides as diagnostic tools to indicate a pre-cancerous condition or cancer, and therapeutic agents based thereon to inhibit CXCR-4 gene expression and / or activity as a method of treating and / or preventing tumorigenesis. 2. BACKGROUND OF THE INVENTION

[0002] 2.1. Brain Tumors

[0003] Brain tumors are among the leading cause of death among young children and adults. A survey by the American Cancer Society has documented that 13,300 people died of brain tumors in 1995 and predicated that over 17,900 would die in 1996 (Parker et al., 1996, CA Cancer J. Clin., 46:5-28). The number of deaths due to brain tumors has been increasing at a significant rate each year. On average, 25,000 Americans are diagnosed with brain...

Claims

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