Bivalent, bispecific antibodies
Patent Information
- Authority / Receiving Office
- US · United States
- Patent Type
- Applications(United States)
- Current Assignee / Owner
- KLEIN CHRISTIAN
- Publication Date
- 2012-06-28
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
PRIORITY TO RELATED APPLICATION(S)
[0001] This application is a division of U.S. application Ser. No. 12 / 332,486, filed Dec. 11, 2008, now pending; which claims the benefit of European Patent Application No. 07024864.6, filed Dec. 21, 2007. The entire contents of the above-identified applications are hereby incorporated by reference.BACKGROUND OF THE INVENTION
[0002] Engineered proteins, such as bi- or multispecific antibodies capable of binding two or more antigens are known in the art. Such multispecific binding proteins can be generated using cell fusion, chemical conjugation, or recombinant DNA techniques.
[0003] A wide variety of recombinant bispecific antibody formats have been developed in the recent past, e.g. tetravalent bispecific antibodies by fusion of, e.g. an IgG antibody format and single chain domains (see e.g. Morrison, S. L., et al, Nature Biotech 15 (1997) 159-163; WO2001077342; and Coloma, M. J., Nature Biotech 25 (2007) 1233-1234).
[0004] Also several other new formats ...