Therapeutic Compositions Comprising Monoterpenes

a technology of monoterpenes and compositions, applied in the direction of biocide, plant growth regulators, pharmaceutical non-active ingredients, etc., can solve the problems of poor prognosis, intractable, and difficult to deliver these drugs to brain tumors, and achieve the effect of enhancing the activity of therapeutic agents
US20120219541A1Inactive Publication Date: 2012-08-30UNIV OF SOUTHERN CALIFORNIA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNIV OF SOUTHERN CALIFORNIA
Publication Date
2012-08-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides a compositions for transport of a therapeutic agent. The compositions contain a therapeutic agent and a monoterpene or an analog thereof. In one aspect, the monoterpene is perillyl alcohol (POH) or an analog thereof. In one aspect, the therapeutic agent is provided in an amount effective to treat the disease or subject of choice.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional application Ser. No. 61 / 150,714, filed Feb. 6, 2009, the contents of which is hereby incorporated by reference in its entirety.BACKGROUND

[0002] Despite the development of drugs that preferentially target tumor cells without harming normal tissues, delivery of these drugs to brain tumors remains a major challenge because of difficulty in penetrating the blood-brain barrier (BBB). Astrocytomas are the most common group of primary brain tumors. Grade III astrocytomas or anaplastic astrocytomas (AA), and grade IV astrocytomas, or glioblastoma multiforme (GBM) tumors have a poor prognosis due to their aggressive growth and resistance to available therapies. Present therapies rely on early detection and the standard treatment of AA and GBM still consists of surgical resection, radiation therapy and chemotherapy. Although chemotherapy may increase the survival of pati...

Claims

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