Parakeratosis inhibitor and skin preparation for external use

a parakeratosis inhibitor and skin technology, applied in the field of parakeratosis inhibitors, can solve the problems of skin problems, skin problems, and skin suffering a great burden, and achieve the effects of preventing/ameliorating skin roughness, preventing and ameliorating skin roughness, and inhibiting the conspicuous conical pore structur

Inactive Publication Date: 2012-10-04
SHISEIDO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The skin preparation effectively inhibits parakeratosis, reduces pore size, and improves skin roughness, providing a more permanent solution with minimal skin damage, as demonstrated by clinical trials and experiments on hairless mice and human subjects.

Problems solved by technology

However, the mechanism for making the pore conspicuous has not been elucidated yet, and use of an astringent lotion and excision of parakeratosis have been usual treatments of parakeratosis.
Or the skin problem has been often covered apparently by means of foundation cream.
Accordingly, the skin suffers a great burden since the skin is temporarily tightened without fundamentally solving the problem of conspicuous pores, and the effect of the astringent lotion has been insufficient.
Physical removal of the keratin plug may damage the skin by a physical force, and side effects on the skin have been a problem.
The effect of this method is not always satisfactory since the effect thereof is temporary and keratin plug is readily regenerated, and removal of keratin plug may only expand the pore.

Method used

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  • Parakeratosis inhibitor and skin preparation for external use
  • Parakeratosis inhibitor and skin preparation for external use
  • Parakeratosis inhibitor and skin preparation for external use

Examples

Experimental program
Comparison scheme
Effect test

embodiments

[0143]The present invention will be described in greater details with reference to some preferred embodiments herein below. The blending quantity is weight % unless otherwise notified.

1. Regarding the Invention 1

first embodiment

Parakeratosis Inhibition Effect Test

[0144]A 3 weight % water solution (including 30 weight % ethanol) was prepared as the evaluation specimen of the glycine derivatives in accordance with the invention 1. The pH was regulated to the range between 7.0 to 7.5, by using hydrochloric acid and sodium hydroxide. When the solubility was low, the solution was adjusted accordingly.

[0145]100 microliters of 10 weight % oleic acid (solvent: ethanol) was applied to the back of hairless mice (HR-1, Hoshino laboratory animals). Thereafter, 100 microliters of sample solution was applied (glycine derivatives in accordance with said invention 1) at each time. This procedure was repeated for 3 days. The day after the application, the skin condition of the backs was observed by using a CCD camera to evaluate the skin roughness (stratified ablation of the skin surface stratum corneum and red spots). The skin condition was evaluated visually, with scoring the skin condition of control application to 2.0 ...

second embodiment

Effect of Shrinking Human Pores

[0148]An experiment of application of sample twice a day for a month on the cheek of healthy male subjects, was conducted with each group consisting of 5 individuals. 3 weight % solution of the glycine derivatives in accordance with the invention 1 (including 15 weight % of ethanol) was prepared. pH was regulated to the range between 7.0 and 7.5, by using hydrochloric acid and / or sodium hydroxide. Control was 15 weight % ethanol solution. Said 3 weight % solution was applied to one side and said control solution was applied to the other side.

[0149]Replicas were prepared prior to and after the application to observe the change of form of pores in the same spot under a three-dimensional laser scanning microscope. The size of pores was evaluated visually 13 steps from 1 to 13 (larger number indicates larger pore size), and the difference between the resulted evaluations before / after the application experiment was then calculated to study the effectiveness...

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PUM

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Abstract

To provide a parakeratosis inhibitor, pore reducing agent and skin roughness preventing / ameliorating agent that exhibit capabilities of parakeratosis inhibition, pore reduction, skin roughness prevention / amelioration, etc., and further provide a skin preparation for external use having these capabilities. There are provided a parakeratosis inhibitor, a pore reducing agent and a skin roughness preventing / ameliorating agent each comprising at least one compound selected from the group consisting of specified glycine derivatives and salts thereof and specified aminosulfuric acid derivatives and salts thereof. Still further, there are provided skin preparations for external use comprising these compounds.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a Division of application Ser. No. 13 / 290,309 filed Nov. 7, 2011, which is a Division of application Ser. No. 10 / 580,471 filed on May 24, 2006, the entire contents of both of which are incorporated herein by reference.TECHNICAL FIELD[0002]The invention relates to a parakeratosis inhibitor that inhibits parakeratosis caused by sebum, a pore-shrinking agent that maintains normal skin conditions around the pore and suppresses a conical structure of the pore from becoming conspicuous by inhibiting parakeratosis caused by stimulatory components in the sebum around the pore, a skin roughness preventing / ameliorating agent that prevents / ameliorates the skin roughness caused by unsaturated fatty acids, and skin preparation for external use that exhibits capabilities of parakeratosis inhibition, pore shrinkage, skin roughness prevention / amelioration, etc.BACKGROUND ART[0003]Recently, many people, young ladies among others, have ...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): C07C309/26A61K8/02A61K8/44A61K8/46A61Q1/02A61Q19/00
CPCA61K8/0212A61K8/44A61Q19/00A61Q1/02A61K8/466A61P17/00
InventorKAMINUMA, MIKIKOSUETSUGU, MASARUIIDA, TOSHIIINOMATA, SHINJITAKADA, KEIKOKATSUTA, YUJI
OwnerSHISEIDO CO LTD