Hyperthermia, system, method, and components

Abstract

An IV pole mountable, therapeutic infusate processing device is incorporated into a hypothermia system to receive therapeutic fluid(s), such as normal saline, peritioneal dialysis solution, or other crystalloid solution, to heat such therapeutic fluid(s) a few degrees centigrade above normal body temperature and to direct the resulting heated infusate to and through a selected anatomical portion of a patients body to raise the temperature of that body portion so as to affect any cancerous or other tumors that may be located therein. The processing device is provided with touch screen controls and visual indicators to facilitate its proper use; while the system further includes temperature and pressure sensors to monitor the hyperthermia processing to insure patient safety.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of Application[0002]This invention relates to the treatment of diseases by raising body temperature; and more particularly to raising the temperature of a specific anatomical portion or portions of a body.[0003]2. Description of the Prior Art[0004]Hyperthermia as a treatment of tumors has been carefully studied and applied. There appear to have been multiple reports of tumor regression coincident with febrile episodes. Some analysis revealed that body temperatures greater than 41 degree. C. are ordinarily needed to induce tumor necrosis (tumor death). Although, there are multiple methods of inducing hyperthermia by either direct skin contact or radiant heating, many physicians have favored an extracorporeal heat exchange (blood) circuit to raise patient body temperatures. Some patients have been maintained at 41.5 degrees to 42 degrees. C. (rectal temperature) for three to four hours without severe cardiovascular compromise; however, others ...

AI Technical Summary

Benefits of technology

[0013]It is yet still another object of this invention to provide new and novel hyperthermia systems and methods, to be used in therapeutic procedures, in which the combination of temperature and fluid flow rate for therapeutic fluid(s) are optimized, by heating the therapeutic fluid to only a few degrees C., above normothermic, and, by circulating, withdrawing and re-circulating such fluid, to and through a body cavity, at a flow rate commensurate with the selected temperature; to provide an efficient hyperthermia system and method which is relatively effective and safe for the patient, and may be operator set.

[0018]It is yet still another object of this invention to provide new and novel and disposable fluid administration sets which are constructed of materials that can be sterilized and made pyrogen free by conventional methods and so that single use thereof is economically feasible.

Problems solved by technology

The inability to respond to heat by dilation, as normal vasculature would, also subjects the tumor to hypoxia, anaerobic metabolism and local acidosis, and these conditions in turn make the tumor tissue more vulnerable to thermal injury.

Ser. No. 5,354,277 and U.S. Pat. No. 5,476,444 are directed to methods and apparatus for effecting whole-body hyperthermia: however, the equipment and procedures disclosed appear to suffer from relatively difficult temperature controls for the fluid handling systems; possible risk of contamination; and possible difficulty to optimize the fluid handling system for a particular indication.

The resulting equipment appears to be large and cumbersome, for the task and for the relatively tight hospital quarters for the patient.

In addition, the heating of therapeutic fluids, that are to pass through the patient's body, and the passing of such fluids through the patient's body, at such elevated temperatures and flow rates, could be damaging to the patient and even more detrimental to the patient then the disease to be treated.

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